Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination


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YOON, Je-Hyun, Kotb ABDELMOHSEN, Jiyoung KIM, Xiaoling YANG, Jennifer L. MARTINDALE, Kumiko TOMINAGA-YAMANAKA, Elizabeth J. WHITE, Arturo V. ORJALO, John L. RINN, Stefan G. KREFT, Gerald M. WILSON, Myriam GOROSPE, 2013. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. In: Nature Communications. 4, 2939. eISSN 2041-1723

@article{Yoon2013Scaff-26044, title={Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination}, year={2013}, doi={10.1038/ncomms3939}, volume={4}, journal={Nature Communications}, author={Yoon, Je-Hyun and Abdelmohsen, Kotb and Kim, Jiyoung and Yang, Xiaoling and Martindale, Jennifer L. and Tominaga-Yamanaka, Kumiko and White, Elizabeth J. and Orjalo, Arturo V. and Rinn, John L. and Kreft, Stefan G. and Wilson, Gerald M. and Gorospe, Myriam}, note={Article Number: 2939} }

<rdf:RDF xmlns:rdf="" xmlns:bibo="" xmlns:dc="" xmlns:dcterms="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>Martindale, Jennifer L.</dc:creator> <dc:contributor>White, Elizabeth J.</dc:contributor> <dc:creator>Kim, Jiyoung</dc:creator> <dc:creator>Abdelmohsen, Kotb</dc:creator> <dcterms:abstract xml:lang="eng">Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates their degradation. HOTAIR levels are highly upregulated in senescent cells, causing rapid decay of targets Ataxin-1 and Snurportin-1, and preventing premature senescence. These results uncover a role for a lncRNA, HOTAIR, as a platform for protein ubiquitination.</dcterms:abstract> <dc:creator>Yoon, Je-Hyun</dc:creator> <dc:contributor>Orjalo, Arturo V.</dc:contributor> <bibo:uri rdf:resource=""/> <dc:contributor>Yang, Xiaoling</dc:contributor> <dc:contributor>Wilson, Gerald M.</dc:contributor> <dc:date rdf:datatype="">2014-01-24T07:38:54Z</dc:date> <dcterms:title>Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination</dcterms:title> <dc:contributor>Tominaga-Yamanaka, Kumiko</dc:contributor> <dc:creator>Tominaga-Yamanaka, Kumiko</dc:creator> <dcterms:available rdf:datatype="">2014-01-24T07:38:54Z</dcterms:available> <dc:rights>deposit-license</dc:rights> <dc:creator>White, Elizabeth J.</dc:creator> <dcterms:bibliographicCitation>Nature Communications ; 4 (2013). - 2939</dcterms:bibliographicCitation> <dc:creator>Wilson, Gerald M.</dc:creator> <dcterms:issued>2013</dcterms:issued> <dc:creator>Yang, Xiaoling</dc:creator> <dc:creator>Gorospe, Myriam</dc:creator> <dc:contributor>Gorospe, Myriam</dc:contributor> <dc:contributor>Kim, Jiyoung</dc:contributor> <dc:contributor>Kreft, Stefan G.</dc:contributor> <dc:creator>Rinn, John L.</dc:creator> <dc:language>eng</dc:language> <dc:creator>Kreft, Stefan G.</dc:creator> <dc:contributor>Abdelmohsen, Kotb</dc:contributor> <dc:contributor>Rinn, John L.</dc:contributor> <dc:contributor>Martindale, Jennifer L.</dc:contributor> <dcterms:rights rdf:resource=""/> <dc:contributor>Yoon, Je-Hyun</dc:contributor> <dc:creator>Orjalo, Arturo V.</dc:creator> </rdf:Description> </rdf:RDF>

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