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Saltatory Evolution of the Ectodermal Neural Cortex Gene Family at the Vertebrate Origin

Saltatory Evolution of the Ectodermal Neural Cortex Gene Family at the Vertebrate Origin


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FEINER, Nathalie, Yasunori MURAKAMI, Lisa BREITHUT, Sylvie MAZAN, Axel MEYER, Shigehiro KURAKU, 2013. Saltatory Evolution of the Ectodermal Neural Cortex Gene Family at the Vertebrate Origin. In: Genome Biology and Evolution. 5(8), pp. 1485-1502. eISSN 1759-6653

@article{Feiner2013Salta-25966, title={Saltatory Evolution of the Ectodermal Neural Cortex Gene Family at the Vertebrate Origin}, year={2013}, doi={10.1093/gbe/evt104}, number={8}, volume={5}, journal={Genome Biology and Evolution}, pages={1485--1502}, author={Feiner, Nathalie and Murakami, Yasunori and Breithut, Lisa and Mazan, Sylvie and Meyer, Axel and Kuraku, Shigehiro} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/25966"> <dc:contributor>Feiner, Nathalie</dc:contributor> <dc:contributor>Breithut, Lisa</dc:contributor> <dcterms:abstract xml:lang="eng">The ectodermal neural cortex (ENC) gene family, whose members are implicated in neurogenesis, is part of the kelch repeat superfamily. To date, ENC genes have been identified only in osteichthyans, although other kelch repeat-containing genes are prevalent throughout bilaterians. The lack of elaborate molecular phylogenetic analysis with exhaustive taxon sampling has obscured the possible link of the establishment of this gene family with vertebrate novelties. In this study, we identified ENC homologs in diverse vertebrates by means of database mining and polymerase chain reaction screens. Our analysis revealed that the ENC3 ortholog was lost in the basal eutherian lineage through single-gene deletion and that the triplication between ENC1, -2, and -3 occurred early in vertebrate evolution. Including our original data on the catshark and the zebrafish, our comparison revealed high conservation of the pleiotropic expression pattern of ENC1 and shuffling of expression domains between ENC1, -2, and -3. Compared with many other gene families including developmental key regulators, the ENC gene family is unique in that conventional molecular phylogenetic inference could identify no obvious invertebrate ortholog. This suggests a composite nature of the vertebrate-specific gene repertoire, consisting not only of de novo genes introduced at the vertebrate origin but also of long-standing genes with no apparent invertebrate orthologs. Some of the latter, including the ENC gene family, may be too rapidly evolving to provide sufficient phylogenetic signals marking orthology to their invertebrate counterparts. Such gene families that experienced saltatory evolution likely remain to be explored and might also have contributed to phenotypic evolution of vertebrates.</dcterms:abstract> <dc:creator>Feiner, Nathalie</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-30T11:57:58Z</dcterms:available> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/25966"/> <dc:creator>Mazan, Sylvie</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:bibliographicCitation>Genome Biology and Evolution ; 5 (2013), 8. - S. 1485-1502</dcterms:bibliographicCitation> <dc:contributor>Mazan, Sylvie</dc:contributor> <dc:creator>Murakami, Yasunori</dc:creator> <dcterms:issued>2013</dcterms:issued> <dc:creator>Meyer, Axel</dc:creator> <dc:contributor>Meyer, Axel</dc:contributor> <dc:creator>Kuraku, Shigehiro</dc:creator> <dc:contributor>Murakami, Yasunori</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Breithut, Lisa</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-30T11:57:58Z</dc:date> <dcterms:title>Saltatory Evolution of the Ectodermal Neural Cortex Gene Family at the Vertebrate Origin</dcterms:title> <dc:rights>deposit-license</dc:rights> <dc:contributor>Kuraku, Shigehiro</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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