Bridging lectin binding sites by multivalent carbohydrates


Dateien zu dieser Ressource

Prüfsumme: MD5:ac9a27b3cb91115601c4d6f68e6dd8a2

WITTMANN, Valentin, Roland J. PIETERS, 2013. Bridging lectin binding sites by multivalent carbohydrates. In: Chemical Society Reviews. 42(10), pp. 4492-4503. ISSN 0306-0012. eISSN 1460-4744

@article{Wittmann2013-05-21Bridg-25853, title={Bridging lectin binding sites by multivalent carbohydrates}, year={2013}, doi={10.1039/C3CS60089K}, number={10}, volume={42}, issn={0306-0012}, journal={Chemical Society Reviews}, pages={4492--4503}, author={Wittmann, Valentin and Pieters, Roland J.} }

Chemical Society Reviews ; 42 (2013), 10. - S. 4492-4503 Pieters, Roland J. Pieters, Roland J. 2014-05-30T22:25:04Z eng 2014-01-14T13:02:00Z Carbohydrate–protein interactions are involved in a multitude of biological recognition processes. Since individual protein–carbohydrate interactions are usually weak, multivalency is often required to achieve biologically relevant binding affinities and selectivities. Among the possible mechanisms responsible for binding enhancement by multivalency, the simultaneous attachment of a multivalent ligand to several binding sites of a multivalent receptor (i.e. chelation) has been proven to have a strong impact. This article summarizes recent examples of chelating lectin ligands of different size. Covered lectins include the Shiga-like toxin, where the shortest distance between binding sites is ca. 9 Å, wheat germ agglutinin (WGA) (shortest distance between binding sites 13–14 Å), LecA from Pseudomonas aeruginosa (shortest distance 26 Å), cholera toxin and heat-labile enterotoxin (shortest distance 31 Å), anti-HIV antibody 2G12 (shortest distance 31 Å), concanavalin A (ConA) (shortest distance 72 Å), RCA<sub>120</sub> (shortest distance 100 Å), and Erythrina cristagalli (ECL) (shortest distance 100 Å). While chelating binding of the discussed ligands is likely, experimental proof, for example by X-ray crystallography, is limited to only a few cases. deposit-license Bridging lectin binding sites by multivalent carbohydrates Wittmann, Valentin 2013-05-21 Wittmann, Valentin

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Wittmann_258532.pdf 285

Das Dokument erscheint in:

KOPS Suche


Mein Benutzerkonto