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Oxytocin modulates proliferation and stress responses of human skin cells : implications for atopic dermatitis

Oxytocin modulates proliferation and stress responses of human skin cells : implications for atopic dermatitis

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DEING, Verena, Dennis ROGGENKAMP, Jochen KÜHNL, Alisa GRUSCHKA, Franz STÄB, Horst WENCK, Alexander BÜRKLE, Gitta NEUFANG, 2013. Oxytocin modulates proliferation and stress responses of human skin cells : implications for atopic dermatitis. In: Experimental Dermatology. 22(6), pp. 399-405. ISSN 0906-6705. eISSN 1600-0625. Available under: doi: 10.1111/exd.12155

@article{Deing2013-06Oxyto-25796, title={Oxytocin modulates proliferation and stress responses of human skin cells : implications for atopic dermatitis}, year={2013}, doi={10.1111/exd.12155}, number={6}, volume={22}, issn={0906-6705}, journal={Experimental Dermatology}, pages={399--405}, author={Deing, Verena and Roggenkamp, Dennis and Kühnl, Jochen and Gruschka, Alisa and Stäb, Franz and Wenck, Horst and Bürkle, Alexander and Neufang, Gitta} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/25796"> <dc:creator>Deing, Verena</dc:creator> <dc:contributor>Kühnl, Jochen</dc:contributor> <dc:creator>Wenck, Horst</dc:creator> <dc:creator>Bürkle, Alexander</dc:creator> <dc:contributor>Gruschka, Alisa</dc:contributor> <dc:contributor>Deing, Verena</dc:contributor> <dc:contributor>Bürkle, Alexander</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>Oxytocin modulates proliferation and stress responses of human skin cells : implications for atopic dermatitis</dcterms:title> <dc:rights>deposit-license</dc:rights> <dcterms:bibliographicCitation>Experimental Dermatology ; 22 (2013), 6. - S. 399-405</dcterms:bibliographicCitation> <dc:creator>Roggenkamp, Dennis</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-10T11:08:19Z</dcterms:available> <dc:contributor>Stäb, Franz</dc:contributor> <dc:creator>Kühnl, Jochen</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:abstract xml:lang="eng">The neuropeptide hormone oxytocin (OXT) mediates a wide spectrum of tissue-specific actions, ranging from cell growth, cell differentiation, sodium excretion to stress responses, reproduction and complex social behaviour. Recently, OXT expression was detected in keratinocytes, but expression of its receptor and function are still unexplored in human skin. Here, we showed that both OXT and its receptor are expressed in primary human dermal fibroblasts and keratinocytes. OXT-induced dose-dependent calcium fluxes in both cell types demonstrating that the OXT receptor (OXTR) is functionally expressed. We also showed that OXT decreases proliferation of dermal fibroblasts and keratinocytes in a dose-dependent manner. In order to further investigate OXT-mediated functions in skin cells, we performed OXTR knockdown experiments. OXTR knockdown in dermal fibroblasts and keratinocytes led to elevated levels of reactive oxygen species and reduced levels of glutathione (GSH). Moreover, OXTR-depleted keratinocytes exhibited an increased release of the pro-inflammatory cytokines IL6, CCL5 and CXCL10. Our data indicate that the OXT system modulates key processes which are dysregulated in atopic dermatitis (AD) such as proliferation, inflammation and oxidative stress responses. Furthermore, we detected a downregulation of the OXT system in peri-lesional and lesional atopic skin. Taken together, these data suggest that the OXT system is a novel neuroendocrine mediator in human skin homoeostasis and clinically relevant to stressed skin conditions like AD.</dcterms:abstract> <dc:creator>Stäb, Franz</dc:creator> <dc:creator>Neufang, Gitta</dc:creator> <dc:language>eng</dc:language> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/25796/2/Deing_257965.pdf"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/25796/2/Deing_257965.pdf"/> <dc:creator>Gruschka, Alisa</dc:creator> <dc:contributor>Neufang, Gitta</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-10T11:08:19Z</dc:date> <dc:contributor>Wenck, Horst</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/25796"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Roggenkamp, Dennis</dc:contributor> <dcterms:issued>2013-06</dcterms:issued> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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