More than apples and oranges : detecting cancer with a fruit fly's antenna


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STRAUCH, Martin, Alja LÜDKE, Daniel MÜNCH, Thomas LAUDES, C. Giovanni GALIZIA, Eugenio MARTINELLI, Luca LAVRA, Roberto PAOLESSE, Alessandra ULIVIERI, Alexandro CATINI, Rosamaria CAPUANO, Corrado DI NATALE, 2014. More than apples and oranges : detecting cancer with a fruit fly's antenna. In: Scientific Reports. 4, 3576. eISSN 2045-2322. Available under: doi: 10.1038/srep03576

@article{Strauch2014apple-25768, title={More than apples and oranges : detecting cancer with a fruit fly's antenna}, year={2014}, doi={10.1038/srep03576}, volume={4}, journal={Scientific Reports}, author={Strauch, Martin and Lüdke, Alja and Münch, Daniel and Laudes, Thomas and Galizia, C. Giovanni and Martinelli, Eugenio and Lavra, Luca and Paolesse, Roberto and Ulivieri, Alessandra and Catini, Alexandro and Capuano, Rosamaria and Di Natale, Corrado}, note={Article Number: 3576} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:contributor>Catini, Alexandro</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Ulivieri, Alessandra</dc:creator> <dc:contributor>Münch, Daniel</dc:contributor> <dc:creator>Di Natale, Corrado</dc:creator> <dcterms:abstract xml:lang="eng">Cancer cells and non-cancer cells differ in their metabolism and they emit distinct volatile compound profiles, allowing to recognise cancer cells by their scent. Insect odorant receptors are excellent chemosensors with high sensitivity and a broad receptive range unmatched by current gas sensors. We thus investigated the potential of utilising the fruit fly's olfactory system to detect cancer cells. Using in vivo calcium imaging, we recorded an array of olfactory receptor neurons on the fruit fly's antenna. We performed multidimensional analysis of antenna responses, finding that cell volatiles from different cell types lead to characteristic response vectors. The distances between these response vectors are conserved across flies and can be used to discriminate healthy mammary epithelial cells from different types of breast cancer cells. This may expand the repertoire of clinical diagnostics, and it is the first step towards electronic noses equipped with biological sensors, integrating artificial and biological olfaction.</dcterms:abstract> <dcterms:available rdf:datatype="">2014-01-17T10:23:35Z</dcterms:available> <dc:contributor>Laudes, Thomas</dc:contributor> <dc:contributor>Galizia, C. Giovanni</dc:contributor> <dc:creator>Münch, Daniel</dc:creator> <dcterms:title>More than apples and oranges : detecting cancer with a fruit fly's antenna</dcterms:title> <dc:contributor>Strauch, Martin</dc:contributor> <dc:date rdf:datatype="">2014-01-17T10:23:35Z</dc:date> <dcterms:isPartOf rdf:resource=""/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>2014</dcterms:issued> <dc:contributor>Ulivieri, Alessandra</dc:contributor> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Lavra, Luca</dc:contributor> <bibo:uri rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dcterms:bibliographicCitation>Scientific Reports ; 4 (2014). - 3576</dcterms:bibliographicCitation> <dc:contributor>Martinelli, Eugenio</dc:contributor> <dcterms:hasPart rdf:resource=""/> <dcterms:rights rdf:resource=""/> <dc:creator>Lüdke, Alja</dc:creator> <dc:creator>Galizia, C. Giovanni</dc:creator> <dc:creator>Martinelli, Eugenio</dc:creator> <dc:creator>Paolesse, Roberto</dc:creator> <dc:contributor>Capuano, Rosamaria</dc:contributor> <dc:creator>Catini, Alexandro</dc:creator> <dc:creator>Strauch, Martin</dc:creator> <dspace:isPartOfCollection rdf:resource=""/> <dc:contributor>Paolesse, Roberto</dc:contributor> <dc:creator>Capuano, Rosamaria</dc:creator> <dc:creator>Laudes, Thomas</dc:creator> <dc:contributor>Lüdke, Alja</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Lavra, Luca</dc:creator> <dc:contributor>Di Natale, Corrado</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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