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N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder

N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder

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MORENO-VILLANUEVA, Maria, Julia MORATH, Valerie VANHOOREN, Thomas ELBERT, Stephan KOLASSA, Claude LIBERT, Alexander BÜRKLE, Iris-Tatjana KOLASSA, 2013. N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder. In: Translational Psychiatry. 3(10), e320. eISSN 2158-3188. Available under: doi: 10.1038/tp.2013.93

@article{MorenoVillanueva2013Nglyc-25705, title={N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder}, year={2013}, doi={10.1038/tp.2013.93}, number={10}, volume={3}, journal={Translational Psychiatry}, author={Moreno-Villanueva, Maria and Morath, Julia and Vanhooren, Valerie and Elbert, Thomas and Kolassa, Stephan and Libert, Claude and Bürkle, Alexander and Kolassa, Iris-Tatjana}, note={Article Number: e320} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/25705"> <dc:creator>Elbert, Thomas</dc:creator> <dc:contributor>Vanhooren, Valerie</dc:contributor> <dc:contributor>Kolassa, Stephan</dc:contributor> <dc:contributor>Bürkle, Alexander</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-09T12:00:59Z</dc:date> <dc:contributor>Elbert, Thomas</dc:contributor> <dc:creator>Libert, Claude</dc:creator> <dc:contributor>Kolassa, Iris-Tatjana</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-09T12:00:59Z</dcterms:available> <dc:language>eng</dc:language> <dc:creator>Kolassa, Iris-Tatjana</dc:creator> <dc:creator>Vanhooren, Valerie</dc:creator> <dc:contributor>Morath, Julia</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/25705/2/Moreno-Villanueva_257056.pdf"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Kolassa, Stephan</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/25705"/> <dc:creator>Moreno-Villanueva, Maria</dc:creator> <dc:contributor>Moreno-Villanueva, Maria</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Bürkle, Alexander</dc:creator> <dcterms:abstract xml:lang="eng">The prevalence of age-related diseases is increased in individuals with post-traumatic stress disorder (PTSD). However, the underlying biological mechanisms are still unclear. N-glycosylation is an age-dependent process, identified as a biomarker for physiological aging (GlycoAge Test). To investigate whether traumatic stress accelerates the aging process, we analyzed the N-glycosylation profile in n=13 individuals with PTSD, n=9 trauma-exposed individuals and in n=10 low-stress control subjects. Individuals with PTSD and trauma-exposed individuals presented an upward shift in the GlycoAge Test, equivalent to an advancement of the aging process by 15 additional years. Trauma-exposed individuals presented an intermediate N-glycosylation profile positioned between severely traumatized individuals with PTSD and low-stress control subjects. In conclusion, our data suggest that cumulative exposure to traumatic stressors accelerates the process of physiological aging.</dcterms:abstract> <dc:contributor>Libert, Claude</dc:contributor> <dcterms:bibliographicCitation>Translational Psychiatry ; 3 (2013). - e320</dcterms:bibliographicCitation> <dcterms:issued>2013</dcterms:issued> <dc:creator>Morath, Julia</dc:creator> <dc:rights>deposit-license</dc:rights> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/25705/2/Moreno-Villanueva_257056.pdf"/> <dcterms:title>N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder</dcterms:title> </rdf:Description> </rdf:RDF>

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