KOPS - Das Institutionelle Repositorium der Universität Konstanz

SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress

SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:6885e9b47546543c9107b499ba2e8f1b

KASSNER, Ingrid, Anneli ANDERSSON, Monika FEY, Martin TOMAS, Elisa MAY, Michael HOTTIGER, 2013. SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress. In: Open Biology. 3(10), pp. 120173-120173. eISSN 2046-2441

@article{Kassner2013-10SET7/-25698, title={SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress}, year={2013}, doi={10.1098/rsob.120173}, number={10}, volume={3}, journal={Open Biology}, pages={120173--120173}, author={Kassner, Ingrid and Andersson, Anneli and Fey, Monika and Tomas, Martin and May, Elisa and Hottiger, Michael} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/25698"> <dc:creator>Hottiger, Michael</dc:creator> <dc:contributor>May, Elisa</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Tomas, Martin</dc:creator> <dcterms:issued>2013-10</dcterms:issued> <dc:creator>May, Elisa</dc:creator> <dc:creator>Fey, Monika</dc:creator> <dc:contributor>Tomas, Martin</dc:contributor> <dc:contributor>Andersson, Anneli</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-17T09:55:59Z</dcterms:available> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:rights>deposit-license</dc:rights> <dc:creator>Kassner, Ingrid</dc:creator> <dcterms:abstract xml:lang="eng">ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1, formerly PARP1) is localized in the nucleus, where it ADP-ribosylates specific target proteins. The post-translational modification (PTM) with a single ADP-ribose unit or with polymeric ADP-ribose (PAR) chains regulates protein function as well as protein–protein interactions and is implicated in many biological processes and diseases. SET7/9 (Setd7, KMT7) is a protein methyltransferase that catalyses lysine monomethylation of histones, but also methylates many non-histone target proteins such as p53 or DNMT1. Here, we identify ARTD1 as a new SET7/9 target protein that is methylated at K508 in vitro and in vivo. ARTD1 auto-modification inhibits its methylation by SET7/9, while auto-poly-ADP-ribosylation is not impaired by prior methylation of ARTD1. Moreover, ARTD1 methylation by SET7/9 enhances the synthesis of PAR upon oxidative stress in vivo. Furthermore, laser irradiation-induced PAR formation and ARTD1 recruitment to sites of DNA damage in a SET7/9-dependent manner. Together, these results reveal a novel mechanism for the regulation of cellular ARTD1 activity by SET7/9 to assure efficient PAR formation upon cellular stress.</dcterms:abstract> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-17T09:55:59Z</dc:date> <dc:creator>Andersson, Anneli</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/25698"/> <dcterms:bibliographicCitation>Open Biology ; 3 (2013), October. - 120173</dcterms:bibliographicCitation> <dc:contributor>Fey, Monika</dc:contributor> <dcterms:title>SET7/9-dependent methylation of ARTD1 at K508 stimulates poly-ADP-ribose formation after oxidative stress</dcterms:title> <dc:contributor>Hottiger, Michael</dc:contributor> <dc:contributor>Kassner, Ingrid</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Kassner_256988.pdf 144

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto