Structural Characterization of Quadruplex DNA with in-cell EPR approaches


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HOLDER, Isabelle T., Malte DRESCHER, Jörg S. HARTIG, 2013. Structural Characterization of Quadruplex DNA with in-cell EPR approaches. In: Bioorganic & Medicinal Chemistry. 21(20), pp. 6156-6161. ISSN 0968-0896. eISSN 1464-3391. Available under: doi: 10.1016/j.bmc.2013.04.014

@article{Holder2013-10-15Struc-25694, title={Structural Characterization of Quadruplex DNA with in-cell EPR approaches}, year={2013}, doi={10.1016/j.bmc.2013.04.014}, number={20}, volume={21}, issn={0968-0896}, journal={Bioorganic & Medicinal Chemistry}, pages={6156--6161}, author={Holder, Isabelle T. and Drescher, Malte and Hartig, Jörg S.} }

Drescher, Malte Structural Characterization of Quadruplex DNA with in-cell EPR approaches Holder, Isabelle T. Bioorganic & Medicinal Chemistry ; 21 (2013), 20. - S. 6156-6161 eng Guanosine-rich DNA sequences have the potential to adopt four-stranded conformations termed quadruplexes. The chromosomes of higher organisms are capped by so-called telomeres that are composed of repeats of the sequence TTAGGG. Up to 200 nucleotides of the G-rich strand form an overhang that is suspected to fold into intramolecular G-quadruplexes. Since induction of quadruplexes at the telomeres results in anti-proliferative effects, the intracellular structure of G-quadruplexes is of high interest as an anti-cancer drug target. Here we give a perspective on the elucidation of DNA sequence folds by electron paramagnetic resonance (EPR) distance measurements. The technique complements X-ray crystallography and NMR spectroscopy, as it can be applied in noncrystalline states, is not intrinsically limited by the size of the bio-macromolecular complex, and is able to analyze flexible structures or coexisting DNA conformation. Hartig, Jörg S. Holder, Isabelle T. Drescher, Malte 2013-10-15 Hartig, Jörg S. 2014-01-17T09:19:00Z 2014-01-17T09:19:00Z terms-of-use

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