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A Roadmap for Hazard Monitoring and Risk Assessment of Marine Biotoxins on the Basis of Chemical and Biological Test Systems

A Roadmap for Hazard Monitoring and Risk Assessment of Marine Biotoxins on the Basis of Chemical and Biological Test Systems

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DANESHIAN, Mardas, Luis M. BOTANA, Marie-Yasmine DECHRAOUI BOTTEIN, Gemma BUCKLAND, Mònica CAMPÀS, Ngaire DENNISON, Robert W. DICKEY, Jorge DIOGÈNE, Valérie FESSARD, Thomas HARTUNG, Andrew HUMPAGE, Marcel LEIST, Jordi MOLGÓ, Michael A. QUILLIAM, Costanza ROVIDA, Benjamin A. SUAREZ-ISLA, Aurelia TUBARO, Kristina WAGNER, Otmar ZOLLER, Daniel DIETRICH, 2013. A Roadmap for Hazard Monitoring and Risk Assessment of Marine Biotoxins on the Basis of Chemical and Biological Test Systems. In: Alternatives to animal experimentation : ALTEX. 30(4), pp. 487-545. ISSN 1868-596X

@article{Daneshian2013Roadm-25642, title={A Roadmap for Hazard Monitoring and Risk Assessment of Marine Biotoxins on the Basis of Chemical and Biological Test Systems}, year={2013}, doi={10.14573/altex.2013.4.487}, number={4}, volume={30}, issn={1868-596X}, journal={Alternatives to animal experimentation : ALTEX}, pages={487--545}, author={Daneshian, Mardas and Botana, Luis M. and Dechraoui Bottein, Marie-Yasmine and Buckland, Gemma and Campàs, Mònica and Dennison, Ngaire and Dickey, Robert W. and Diogène, Jorge and Fessard, Valérie and Hartung, Thomas and Humpage, Andrew and Leist, Marcel and Molgó, Jordi and Quilliam, Michael A. and Rovida, Costanza and Suarez-Isla, Benjamin A. and Tubaro, Aurelia and Wagner, Kristina and Zoller, Otmar and Dietrich, Daniel} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/25642"> <dc:contributor>Dechraoui Bottein, Marie-Yasmine</dc:contributor> <dc:contributor>Diogène, Jorge</dc:contributor> <dc:contributor>Dickey, Robert W.</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Campàs, Mònica</dc:creator> <dc:creator>Quilliam, Michael A.</dc:creator> <dc:contributor>Tubaro, Aurelia</dc:contributor> <dc:creator>Tubaro, Aurelia</dc:creator> <dcterms:issued>2013</dcterms:issued> <dc:creator>Dennison, Ngaire</dc:creator> <dc:contributor>Leist, Marcel</dc:contributor> <dc:creator>Dickey, Robert W.</dc:creator> <dc:creator>Suarez-Isla, Benjamin A.</dc:creator> <dc:creator>Zoller, Otmar</dc:creator> <dc:contributor>Campàs, Mònica</dc:contributor> <dc:creator>Humpage, Andrew</dc:creator> <dc:creator>Hartung, Thomas</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-13T10:08:48Z</dc:date> <dc:language>eng</dc:language> <dc:contributor>Humpage, Andrew</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:contributor>Molgó, Jordi</dc:contributor> <dc:contributor>Daneshian, Mardas</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/25642"/> <dc:creator>Dechraoui Bottein, Marie-Yasmine</dc:creator> <dc:contributor>Zoller, Otmar</dc:contributor> <dc:creator>Diogène, Jorge</dc:creator> <dc:creator>Dietrich, Daniel</dc:creator> <dc:contributor>Fessard, Valérie</dc:contributor> <dc:contributor>Rovida, Costanza</dc:contributor> <dc:creator>Daneshian, Mardas</dc:creator> <dc:contributor>Quilliam, Michael A.</dc:contributor> <dcterms:bibliographicCitation>Alternatives to animal experimentation : ALTEX ; 30 (2013), 4. - S. 487-545</dcterms:bibliographicCitation> <dc:creator>Molgó, Jordi</dc:creator> <dc:contributor>Dennison, Ngaire</dc:contributor> <dc:contributor>Botana, Luis M.</dc:contributor> <dcterms:abstract xml:lang="eng">Aquatic food accounts for over 40% of global animal food products, and the potential contamination with toxins of algal origin – marine biotoxins – poses a health threat for consumers. The gold standards to assess toxins in aquatic food have traditionally been in vivo methods, i.e., the mouse as well as the rat bioassay. Besides ethical concerns, there is also a need for more reliable test methods because of low inter-species comparability, high intra-species variability, the high number of false positive and negative results as well as questionable extrapolation of quantitative risk to humans. For this reason, a transatlantic group of experts in the field of marine biotoxins was convened from academia and regulatory safety authorities to discuss future approaches to marine biotoxin testing. In this report they provide a background on the toxin classes, on their chemical characterization, the epidemiology, on risk assessment and management, as well as on their assumed mode of action. Most importantly, physiological functional assays such as in vitro bioassays and also analytical techniques, e.g., liquid chromatography coupled mass spectrometry (LC-MS), as substitutes for the rodent bioassay are reviewed. This forms the basis for recommendations on methodologies for hazard monitoring and risk assessment, establishment of causality of intoxications in human cases, a roadmap for research and development of human-relevant functional assays, as well as new approaches for a consumer directed safety concept.</dcterms:abstract> <dc:creator>Buckland, Gemma</dc:creator> <dc:contributor>Dietrich, Daniel</dc:contributor> <dc:contributor>Hartung, Thomas</dc:contributor> <dc:contributor>Wagner, Kristina</dc:contributor> <dc:creator>Leist, Marcel</dc:creator> <dc:contributor>Suarez-Isla, Benjamin A.</dc:contributor> <dc:creator>Rovida, Costanza</dc:creator> <dc:creator>Wagner, Kristina</dc:creator> <dc:contributor>Buckland, Gemma</dc:contributor> <dc:creator>Botana, Luis M.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2014-01-13T10:08:48Z</dcterms:available> <dc:creator>Fessard, Valérie</dc:creator> <dcterms:title>A Roadmap for Hazard Monitoring and Risk Assessment of Marine Biotoxins on the Basis of Chemical and Biological Test Systems</dcterms:title> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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