Role of G proteins in olfactory signaling of Drosophila


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IGNATIOUS RAJA, Jennifer Sinthiya, 2013. Role of G proteins in olfactory signaling of Drosophila [Dissertation]. Konstanz: University of Konstanz

@phdthesis{IgnatiousRaja2013prote-25038, title={Role of G proteins in olfactory signaling of Drosophila}, year={2013}, author={Ignatious Raja, Jennifer Sinthiya}, address={Konstanz}, school={Universität Konstanz} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:hasPart rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dspace:isPartOfCollection rdf:resource=""/> <dc:creator>Ignatious Raja, Jennifer Sinthiya</dc:creator> <dcterms:issued>2013</dcterms:issued> <dc:contributor>Ignatious Raja, Jennifer Sinthiya</dc:contributor> <dspace:hasBitstream rdf:resource=""/> <bibo:uri rdf:resource=""/> <dc:date rdf:datatype="">2013-11-05T10:16:19Z</dc:date> <dcterms:rights rdf:resource=""/> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">Intracellular signaling in insect olfactory receptor neurons remains unclear, with both metabotropic and ionotropic components being discussed. This doctoral thesis investigates the role of heterotrimeric G proteins in olfactory signaling of insects. Drosophila odorant receptors, Or22a and Or92a were used as the model for insect ORs and the role of G proteins; Go/i subgroup or Go and Gq proteins respectively, in these neurons for olfactory signaling was studied by combined in vivo and in vitro approach. Go/i subgroup of G proteins contributed to the odor responses both for the fast (phasic) and for the slow (tonic) response component and the signaling is mediated by the Gβγ subunits of the heterotrimeric Go/i proteins. In vivo disruption of Go and Gq modulated the odor response of Or92a neurons in the periphery and also played a role in pre-synaptic excitation and inhibition possibly via the activity of neurotransmitters. From these results we could conclude that different ORs activate a G protein to a varying degree and an OR can activate more than one G protein upon odor detection. In general we could conclude that insects use multiple pathways for olfactory signaling, and activates diverse G proteins (metabotropic signaling pathway) upon odor detection. These results add an intriguing component to the still open full picture of insect olfactory transduction.</dcterms:abstract> <dcterms:isPartOf rdf:resource=""/> <dc:rights>terms-of-use</dc:rights> <dcterms:title>Role of G proteins in olfactory signaling of Drosophila</dcterms:title> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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