(4R)- and (4S)-fluoroproline in the conserved cis-prolyl peptide bond of the thioredoxin fold : tertiary structure context dictates ring puckering

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2013
Autor:innen
Schärer, Martin
Capitani, Guido
Glockshuber, Rudi
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
ArXiv-ID
Internationale Patentnummer
EU-Projektnummer
DFG-Projektnummer
Projekt
Open Access-Veröffentlichung
Sammlungen
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
unikn.publication.listelement.citation.prefix.version.undefined
ChemBioChem. 2013, 14(9), pp. 1053-1057. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201300178
Zusammenfassung

Fine-tuning protein stability: The non-natural amino acids (2S,4R)- and (2S,4S)-fluoroproline modulate protein stability by biasing the proline ring pucker and the cis/trans equilibrium of prolyl peptide bonds. We incorporated both fluoroproline stereoisomers at the invariant cis-proline residue of the thioredoxin fold. The results show that tertiary structure context overrules the conformational preferences of fluoroprolines.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
540 Chemie
Schlagwörter
cis peptide bonds, fluoroprolines, proline ring puckers, protein engineering, protein structures
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690RUBINI, Marina, Martin SCHÄRER, Guido CAPITANI, Rudi GLOCKSHUBER, 2013. (4R)- and (4S)-fluoroproline in the conserved cis-prolyl peptide bond of the thioredoxin fold : tertiary structure context dictates ring puckering. In: ChemBioChem. 2013, 14(9), pp. 1053-1057. ISSN 1439-4227. eISSN 1439-7633. Available under: doi: 10.1002/cbic.201300178
BibTex
@article{Rubini2013-06-174Sflu-24514,
  year={2013},
  doi={10.1002/cbic.201300178},
  title={(4R)- and (4S)-fluoroproline in the conserved cis-prolyl peptide bond of the thioredoxin fold : tertiary structure context dictates ring puckering},
  number={9},
  volume={14},
  issn={1439-4227},
  journal={ChemBioChem},
  pages={1053--1057},
  author={Rubini, Marina and Schärer, Martin and Capitani, Guido and Glockshuber, Rudi}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/24514">
    <dcterms:title>(4R)- and (4S)-fluoroproline in the conserved cis-prolyl peptide bond of the thioredoxin fold : tertiary structure context dictates ring puckering</dcterms:title>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-10-01T10:23:19Z</dcterms:available>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dcterms:issued>2013-06-17</dcterms:issued>
    <dc:language>eng</dc:language>
    <dcterms:bibliographicCitation>ChemBioChem ; 14 (2013), 9. - S. 1053-1057</dcterms:bibliographicCitation>
    <dc:creator>Schärer, Martin</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/24514"/>
    <dc:contributor>Capitani, Guido</dc:contributor>
    <dc:contributor>Glockshuber, Rudi</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:creator>Glockshuber, Rudi</dc:creator>
    <dc:contributor>Schärer, Martin</dc:contributor>
    <dc:creator>Rubini, Marina</dc:creator>
    <dc:contributor>Rubini, Marina</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-10-01T10:23:19Z</dc:date>
    <dc:rights>terms-of-use</dc:rights>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Capitani, Guido</dc:creator>
    <dcterms:abstract xml:lang="eng">Fine-tuning protein stability: The non-natural amino acids (2S,4R)- and (2S,4S)-fluoroproline modulate protein stability by biasing the proline ring pucker and the cis/trans equilibrium of prolyl peptide bonds. We incorporated both fluoroproline stereoisomers at the invariant cis-proline residue of the thioredoxin fold. The results show that tertiary structure context overrules the conformational preferences of fluoroprolines.</dcterms:abstract>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet