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The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles

The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles

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VINOD, P.K., Xin ZHOU, Tongli ZHANG, Thomas MAYER, Bela NOVAK, 2013. The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles. In: Biophysical Chemistry. 177-178, pp. 1-6. ISSN 0301-4622. eISSN 1873-4200

@article{Vinod2013-07APC/C-24228, title={The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles}, year={2013}, doi={10.1016/j.bpc.2013.03.002}, volume={177-178}, issn={0301-4622}, journal={Biophysical Chemistry}, pages={1--6}, author={Vinod, P.K. and Zhou, Xin and Zhang, Tongli and Mayer, Thomas and Novak, Bela} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/24228"> <dc:language>eng</dc:language> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/24228"/> <dcterms:issued>2013-07</dcterms:issued> <dc:rights>deposit-license</dc:rights> <dc:creator>Mayer, Thomas</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-08-23T12:07:35Z</dcterms:available> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Zhang, Tongli</dc:contributor> <dc:contributor>Novak, Bela</dc:contributor> <dc:contributor>Zhou, Xin</dc:contributor> <dcterms:bibliographicCitation>Biophysical Chemistry ; 177-178 (2013). - S. 1-6</dcterms:bibliographicCitation> <dc:creator>Zhang, Tongli</dc:creator> <dcterms:abstract xml:lang="eng">The early embryonic Xenopus cell cycles are characterized by alternating oscillations of Cyclin-dependent kinase-1 (Cdk1) and Anaphase Promoting Complex/Cyclosome (APC/C) activities. The early cycles before midblastula transition lack significant inhibitory Cdk1 phosphorylations and are driven by periodic accumulation of Cyclin B before M phase and its degradation by APC/C at the end of M phase. Both experiments and mathematical modelling suggest that while Cdk1:CycB phosphorylation activates APC/C, it inhibits its co-activator Cdc20 (Fizzy). These interactions create an amplified negative-feedback loop which is at the heart of all cell cycle oscillations. Recent experiments find that the APC/C inhibitor, Emi2/XErp1 is essential for large amplitude and short period Cyclin B oscillations during early divisions in the intact Xenopus embryo. This finding is counter-intuitive since larger amplitudes should come with slower cycle times. We explain this paradox by analysing the amplified negative feedback model extended with APC/C inhibition by Emi2. We show that Emi2 interferes with the intrinsic time-delay in APC/C activation and inactivation to increase the amplitude as well as shorten the period of Cyclin B oscillation.</dcterms:abstract> <dc:contributor>Vinod, P.K.</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-08-23T12:07:35Z</dc:date> <dc:creator>Vinod, P.K.</dc:creator> <dc:creator>Novak, Bela</dc:creator> <dc:contributor>Mayer, Thomas</dc:contributor> <dc:creator>Zhou, Xin</dc:creator> <dcterms:title>The role of APC/C inhibitor Emi2/XErp1 in oscillatory dynamics of early embryonic cell cycles</dcterms:title> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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