Ca2+ signalling early in evolution - all but primitive


Dateien zu dieser Ressource

Prüfsumme: MD5:1d3e9e8cda80983642c5a403f91583ba

PLATTNER, Helmut, Alexei VERKHRATSKY, 2013. Ca2+ signalling early in evolution - all but primitive. In: Journal of Cell Science. 126(10), pp. 2141-2150. ISSN 0021-9533. eISSN 1477-9137

@article{Plattner2013-05-15signa-24179, title={Ca2+ signalling early in evolution - all but primitive}, year={2013}, doi={10.1242/jcs.127449}, number={10}, volume={126}, issn={0021-9533}, journal={Journal of Cell Science}, pages={2141--2150}, author={Plattner, Helmut and Verkhratsky, Alexei} }

Plattner, Helmut deposit-license 2013-07-31T09:04:38Z Plattner, Helmut eng 2013-05-15 Ca<sup>2+</sup> signalling early in evolution - all but primitive Verkhratsky, Alexei Early in evolution, Ca(2+) emerged as the most important second messenger for regulating widely different cellular functions. In eukaryotic cells Ca(2+) signals originate from several sources, i.e. influx from the outside medium, release from internal stores or from both. In mammalian cells, Ca(2+)-release channels represented by inositol 1,4,5-trisphosphate receptors and ryanodine receptors (InsP3R and RyR, respectively) are the most important. In unicellular organisms and plants, these channels are characterised with much less precision. In the ciliated protozoan, Paramecium tetraurelia, 34 molecularly distinct Ca(2+)-release channels that can be grouped in six subfamilies, based on criteria such as domain structure, pore, selectivity filter and activation mechanism have been identified. Some of these channels are genuine InsP3Rs and some are related to RyRs. Others show some--but not all--features that are characteristic for one or the other type of release channel. Localisation and gene silencing experiments revealed widely different--yet distinct--localisation, activation and functional engagement of the different Ca(2+)-release channels. Here, we shall discuss early evolutionary routes of Ca(2+)-release machinery in protozoa and demonstrate that detailed domain analyses and scrutinised functional analyses are instrumental for in-depth evolutionary mapping of Ca(2+)-release channels in unicellular organisms. Journal of Cell Science ; 126 (2013), 10. - S. 2141-2150 Verkhratsky, Alexei 2013-07-31T09:04:38Z

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Plattner_241795.pdf 83

Das Dokument erscheint in:

KOPS Suche


Mein Benutzerkonto