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Nature's way of handling a greenhouse gas : the copper-sulfur cluster of purple nitrous oxide reductase

Nature's way of handling a greenhouse gas : the copper-sulfur cluster of purple nitrous oxide reductase

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WÜST, Anja, Lisa SCHNEIDER, Anja POMOWSKI, Walter G. ZUMFT, Peter KRONECK, Oliver EINSLE, 2012. Nature's way of handling a greenhouse gas : the copper-sulfur cluster of purple nitrous oxide reductase. In: Biological Chemistry. 393(10), pp. 1067-77-1077. ISSN 1431-6730. eISSN 1437-4315. Available under: doi: 10.1515/hsz-2012-0177

@article{Wust2012-10Natur-23614, title={Nature's way of handling a greenhouse gas : the copper-sulfur cluster of purple nitrous oxide reductase}, year={2012}, doi={10.1515/hsz-2012-0177}, number={10}, volume={393}, issn={1431-6730}, journal={Biological Chemistry}, pages={1067-77--1077}, author={Wüst, Anja and Schneider, Lisa and Pomowski, Anja and Zumft, Walter G. and Kroneck, Peter and Einsle, Oliver} }

Schneider, Lisa Biological Chemistry ; 393 (2012), 10. - S. 1067-1077 2013-06-14T09:29:50Z Nature's way of handling a greenhouse gas : the copper-sulfur cluster of purple nitrous oxide reductase Zumft, Walter G. Pomowski, Anja Wüst, Anja Kroneck, Peter deposit-license Zumft, Walter G. Einsle, Oliver Pomowski, Anja The tetranuclear Cu<sub>Z</sub> cluster is the unique active site of nitrous oxide reductase, the enzyme that catalyzes the reduction of nitrous oxide to dinitrogen as the final reaction in bacterial denitrification. Three-dimensional structures of orthologs of the enzyme from a variety of different bacterial species were essential steps in the elucidation of the properties of this center. However, while structural data first revealed and later confirmed the presence of four copper ions in spectroscopically distinct forms of Cu<sub>Z</sub>, the exact structure and stoichiometry of the cluster showed significant variations. A ligand bridging ions Cu<sub>Z1</sub> and Cu<sub>Z2</sub> was initially assigned as a water or hydroxo species in the structures from Pseudomonas nautica (now Marinobacter hydrocarbonoclasticus) and Paracoccus denitrificans. This ligand was absent in a structure from "Achromobacter cycloclastes", and could be reconstituted by iodide that acted as an inhibitor of catalysis. A recent structure of anoxically isolated nitrous oxide reductase from Pseudomonas stutzeri revealed the bridging ligand to be sulfide, S<sup>2-</sup>, and showed an unprecedented side-on mode of nitrous oxide binding to this form of Cu<sub>Z</sub>. Einsle, Oliver Wüst, Anja 2012-10 2013-06-14T09:29:50Z Kroneck, Peter Schneider, Lisa eng

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