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Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E<sub>2</sub>

Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E2

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BRUCKNER, Markus, Denise DICKEL, Eva SINGER, Daniel LEGLER, 2012. Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E2. In: Cellular Immunology. 276(1-2), pp. 52-58. ISSN 0008-8749. eISSN 1090-2163

@article{Bruckner2012-03Disti-23561, title={Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E2}, year={2012}, doi={10.1016/j.cellimm.2012.03.008}, number={1-2}, volume={276}, issn={0008-8749}, journal={Cellular Immunology}, pages={52--58}, author={Bruckner, Markus and Dickel, Denise and Singer, Eva and Legler, Daniel} }

eng Cellular Immunology ; 276 (2012), 1-2. - S. 52-58 Legler, Daniel deposit-license Singer, Eva Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E<sub>2</sub> Singer, Eva Legler, Daniel 2013-06-11T13:57:56Z Dendritic cells (DCs) are key in regulating immune responses. DCs reside in tissues facing the environment and sample their surrounding for pathogens. Upon pathogen encounter, DCs mature and migrate into secondary lymphoid organs. Distinct maturation signals dictate the ability of DCs to produce distinct patterns of chemokines that orchestrate immunity. Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) is produced during inflammation and modulates DC functions. We demonstrate that PGE<sub>2</sub> modulates distinct chemokine expression patterns of human monocyte-derived (Mo) DCs upon maturation with various stimuli. PGE<sub>2</sub> dampened early production of the inflammatory chemokines CCL2, CCL4, CCL5 and attenuated the expression of the T cell attractant CXCL10. In contrast, PGE<sub>2</sub> enhanced CXCL8 production early during maturation, whereas CXCL16 levels were continuously elevated, contributing to innate immune cell recruitment. Moreover, PGE<sub>2</sub> induces transcription of the homeostatic chemokines CCL17 and CCL22. Finally, mature MoDCs produced the homing chemokine CCL19 and its expression was down-regulated by PGE<sub>2</sub>. 2013-06-11T13:57:56Z 2012-03 Dickel, Denise Bruckner, Markus Dickel, Denise Bruckner, Markus

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