KOPS - Das Institutionelle Repositorium der Universität Konstanz

Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration

Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

BLUM, Nicola, Gerrit BEGEMANN, 2012. Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration. In: Development. 139(1), pp. 107-116. ISSN 0950-1991. eISSN 1477-9129

@article{Blum2012-01Retin-23556, title={Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration}, year={2012}, doi={10.1242/dev.065391}, number={1}, volume={139}, issn={0950-1991}, journal={Development}, pages={107--116}, author={Blum, Nicola and Begemann, Gerrit} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/23556"> <dcterms:title>Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration</dcterms:title> <dcterms:bibliographicCitation>Development ; 139 (2012), 1. - S. 107-116</dcterms:bibliographicCitation> <dcterms:abstract xml:lang="eng">Adult teleosts rebuild amputated fins through a proliferation-dependent process called epimorphic regeneration, in which a blastema of cycling progenitor cells replaces the lost fin tissue. The genetic networks that control formation of blastema cells from formerly quiescent stump tissue and subsequent blastema function are still poorly understood. Here, we investigated the cellular and molecular consequences of genetically interfering with retinoic acid (RA) signaling for the formation of the zebrafish blastema. We show that RA signaling is upregulated within the first few hours after fin amputation in the stump mesenchyme, where it controls Fgf, Wnt/β-catenin and Igf signaling. Genetic inhibition of the RA pathway at this stage blocks blastema formation by inhibiting cell cycle entry of stump cells and impairs the formation of the basal epidermal layer, a signaling center in the wound epidermis. In the established blastema, RA signaling remains active to ensure the survival of the highly proliferative blastemal population by controlling expression of the anti-apoptotic factor bcl2. In addition, RA signaling maintains blastema proliferation through the activation of growth-stimulatory signals mediated by Fgf and Wnt/β-catenin signaling, as well as by reducing signaling through the growth-inhibitory non-canonical Wnt pathway. The endogenous roles of RA in adult vertebrate appendage regeneration are uncovered here for the first time. They provide a mechanistic framework to understand previous observations in salamanders that link endogenous sources of RA to the regeneration process itself and support the hypothesis that the RA signaling pathway is an essential component of vertebrate tissue regeneration.</dcterms:abstract> <dcterms:issued>2012-01</dcterms:issued> <dc:contributor>Blum, Nicola</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:rights>deposit-license</dc:rights> <dc:language>eng</dc:language> <dc:contributor>Begemann, Gerrit</dc:contributor> <dc:creator>Blum, Nicola</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-06-10T12:40:52Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-06-10T12:40:52Z</dc:date> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/23556"/> <dc:creator>Begemann, Gerrit</dc:creator> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto