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General relationship between transit compartments and lifespan models

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KOCH, Gilbert, Johannes SCHROPP, 2012. General relationship between transit compartments and lifespan models. In: Journal of Pharmacokinetics and Pharmacodynamics. 39(4), pp. 343-355. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-012-9254-4

@article{Koch2012-08Gener-22787, title={General relationship between transit compartments and lifespan models}, year={2012}, doi={10.1007/s10928-012-9254-4}, number={4}, volume={39}, issn={1567-567X}, journal={Journal of Pharmacokinetics and Pharmacodynamics}, pages={343--355}, author={Koch, Gilbert and Schropp, Johannes} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:contributor>Schropp, Johannes</dc:contributor> <dcterms:issued>2012-08</dcterms:issued> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:abstract xml:lang="eng">Transit compartment models (TCM) are important tools in pharmacokinetic/pharmacodynamic (PKPD) modeling. In this work we investigate the relationship between TCMs with arbitrary initial values and lifespan models (LSM) with non-constant past and constant lifespan. We show that the total population in all transit compartments converges to a LSM, if the number of compartments n tends to infinity. The key to obtain this result is to establish a relationship between the initial values of the TCM and the non-constant past of the LSM. We apply the result to two already published PKPD models.</dcterms:abstract> <dcterms:rights rdf:resource=""/> <dc:language>eng</dc:language> <dspace:isPartOfCollection rdf:resource=""/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource=""/> <dc:contributor>Koch, Gilbert</dc:contributor> <dc:creator>Koch, Gilbert</dc:creator> <dcterms:title>General relationship between transit compartments and lifespan models</dcterms:title> <dcterms:available rdf:datatype="">2013-05-16T10:14:06Z</dcterms:available> <dc:rights>terms-of-use</dc:rights> <dc:creator>Schropp, Johannes</dc:creator> <dcterms:bibliographicCitation>Journal of Pharmacokinetics and Pharmacodynamics ; 39 (2012), 4. - S. 343-355</dcterms:bibliographicCitation> <dc:date rdf:datatype="">2013-05-16T10:14:06Z</dc:date> <bibo:uri rdf:resource=""/> </rdf:Description> </rdf:RDF>

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