General relationship between transit compartments and lifespan models

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KOCH, Gilbert, Johannes SCHROPP, 2012. General relationship between transit compartments and lifespan models. In: Journal of Pharmacokinetics and Pharmacodynamics. 39(4), pp. 343-355. ISSN 1567-567X. eISSN 1573-8744

@article{Koch2012-08Gener-22787, title={General relationship between transit compartments and lifespan models}, year={2012}, doi={10.1007/s10928-012-9254-4}, number={4}, volume={39}, issn={1567-567X}, journal={Journal of Pharmacokinetics and Pharmacodynamics}, pages={343--355}, author={Koch, Gilbert and Schropp, Johannes} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/22787"> <dc:contributor>Schropp, Johannes</dc:contributor> <dcterms:issued>2012-08</dcterms:issued> <dcterms:abstract xml:lang="eng">Transit compartment models (TCM) are important tools in pharmacokinetic/pharmacodynamic (PKPD) modeling. In this work we investigate the relationship between TCMs with arbitrary initial values and lifespan models (LSM) with non-constant past and constant lifespan. We show that the total population in all transit compartments converges to a LSM, if the number of compartments n tends to infinity. The key to obtain this result is to establish a relationship between the initial values of the TCM and the non-constant past of the LSM. We apply the result to two already published PKPD models.</dcterms:abstract> <dc:language>eng</dc:language> <dc:rights>deposit-license</dc:rights> <dc:contributor>Koch, Gilbert</dc:contributor> <dc:creator>Koch, Gilbert</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:title>General relationship between transit compartments and lifespan models</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-05-16T10:14:06Z</dcterms:available> <dc:creator>Schropp, Johannes</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-05-16T10:14:06Z</dc:date> <dcterms:bibliographicCitation>Journal of Pharmacokinetics and Pharmacodynamics ; 39 (2012), 4. - S. 343-355</dcterms:bibliographicCitation> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22787"/> </rdf:Description> </rdf:RDF>

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