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Nitroimidazoles Part 7 : Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives

Nitroimidazoles Part 7 : Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives

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AL-MASOUDI, Najim A., Wolfgang PFLEIDERER, Christophe PANNECOUQUE, 2012. Nitroimidazoles Part 7 : Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives. In: Zeitschrift für Naturforschung B. 67(8). ISSN 1865-7117

@article{Al-Masoudi2012Nitro-22647, title={Nitroimidazoles Part 7 : Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives}, year={2012}, doi={10.5560/ZNB.2012-0122}, number={8}, volume={67}, issn={1865-7117}, journal={Zeitschrift für Naturforschung B}, author={Al-Masoudi, Najim A. and Pfleiderer, Wolfgang and Pannecouque, Christophe} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/22647"> <dcterms:title>Nitroimidazoles Part 7 : Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-05-06T13:31:30Z</dc:date> <dc:contributor>Al-Masoudi, Najim A.</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Pannecouque, Christophe</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22647"/> <dc:language>eng</dc:language> <dc:creator>Al-Masoudi, Najim A.</dc:creator> <dc:contributor>Pannecouque, Christophe</dc:contributor> <dcterms:bibliographicCitation>Zeitschrift für Naturforschung B ; 67b (2012), 8. - S. 835-842</dcterms:bibliographicCitation> <dc:contributor>Pfleiderer, Wolfgang</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-05-06T13:31:30Z</dcterms:available> <dc:creator>Pfleiderer, Wolfgang</dc:creator> <dcterms:issued>2012</dcterms:issued> <dcterms:abstract xml:lang="eng">Reverse transcriptase enzyme (RT) is an attractive target for the development of new drugs useful in AIDS therapy and HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs), and offers the possibility of generating structures of increased potency. On this basis, a series of 4-oxo-3-phenyl-2-(phenylimino)thiazolidin-5-ylidene, 3-hydroxypropyl, 3-azidopropyl, and 3-aminopropyl derivatives of 1-benzyl-2-ethyl-4-nitroimidazoles 6–8, as well as the substituted 1,2,3-triazolo analogs 12–14, the diazepam 15 and carboxamide derivatives 16 and 17 were synthesized. All compounds have been evaluated for their anti-HIV activity.</dcterms:abstract> <dc:rights>deposit-license</dc:rights> </rdf:Description> </rdf:RDF>

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