KOPS - The Institutional Repository of the University of Konstanz

Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation

Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation

Cite This

Files in this item

Checksum: MD5:dd4beee88dfb82b2badecef698c7609a

SCHIERLE, Gabriele S. Kaminski, Oskar HANSSON, Elisa FERRANDO-MAY, Pierluigi NICOTERA, Patrik BRUNDIN, Marcel LEIST, 1999. Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation. In: NeuroReport. 10(16), pp. 3347-3351. ISSN 0959-4965. eISSN 1473-558X

@article{Schierle1999Neuro-22370, title={Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation}, year={1999}, number={16}, volume={10}, issn={0959-4965}, journal={NeuroReport}, pages={3347--3351}, author={Schierle, Gabriele S. Kaminski and Hansson, Oskar and Ferrando-May, Elisa and Nicotera, Pierluigi and Brundin, Patrik and Leist, Marcel} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/22370"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-04-03T09:55:46Z</dc:date> <dcterms:abstract xml:lang="eng">The exact causes of the extensive cell death in nigral transplants are still unknown. Since poly-(ADP-ribose) polymerase (PARP) overactivation has been implicated in neuronal death, we examined the effects of PARP on the survival of nigral grafts by using donor tissue from PARP knock-out or wild-type mice. Eight hours after preparation of the nigral cell suspension, cell damage was quantified by measurement of lactate dehydrogenase release, DNA fragmentation and caspase activation. At this stage, PARP deletion had no protective effect. Moreover, neither the survival of transplanted dopaminergic neurons, nor the functional recovery of hemiparkinsonian graft recipients were improved by the absence of PARP. We conclude that cell death in embryonic nigral grafts is not affected by the absence of PARP activation.</dcterms:abstract> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Hansson, Oskar</dc:creator> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Hansson, Oskar</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>1999</dcterms:issued> <dc:contributor>Leist, Marcel</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/22370/1/Schierle_223706.pdf"/> <dc:contributor>Nicotera, Pierluigi</dc:contributor> <dc:creator>Nicotera, Pierluigi</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Ferrando-May, Elisa</dc:contributor> <dc:language>eng</dc:language> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/22370/1/Schierle_223706.pdf"/> <dc:creator>Schierle, Gabriele S. Kaminski</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-04-03T09:55:46Z</dcterms:available> <dcterms:bibliographicCitation>NeuroReport ; 10 (1999), 16. - S. 3347-3351</dcterms:bibliographicCitation> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:title>Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation</dcterms:title> <dc:creator>Brundin, Patrik</dc:creator> <dc:contributor>Schierle, Gabriele S. Kaminski</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22370"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Leist, Marcel</dc:creator> <dc:creator>Ferrando-May, Elisa</dc:creator> <dc:contributor>Brundin, Patrik</dc:contributor> </rdf:Description> </rdf:RDF>

Downloads since Oct 1, 2014 (Information about access statistics)

Schierle_223706.pdf 177

This item appears in the following Collection(s)

Search KOPS


Browse

My Account