KOPS - The Institutional Repository of the University of Konstanz

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

GRÖTTRUP, Marcus, Agnes BARON, Gillian GRIFFITHS, Ronald PALACIOS, Harald von BOEHMER, 1992. T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines. In: EMBO Journal. 11(7), pp. 2735-2745. ISSN 0261-4189. eISSN 1460-2075

@article{Grottrup1992recep-22361, title={T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines}, year={1992}, number={7}, volume={11}, issn={0261-4189}, journal={EMBO Journal}, pages={2735--2745}, author={Gröttrup, Marcus and Baron, Agnes and Griffiths, Gillian and Palacios, Ronald and Boehmer, Harald von} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/22361"> <dc:contributor>Griffiths, Gillian</dc:contributor> <dcterms:title>T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-04-03T08:52:16Z</dc:date> <dc:language>eng</dc:language> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-04-03T08:52:16Z</dcterms:available> <dc:contributor>Boehmer, Harald von</dc:contributor> <dcterms:bibliographicCitation>EMBO Journal ; 11 (1992), 7. - S. 2735-2745</dcterms:bibliographicCitation> <dc:creator>Griffiths, Gillian</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22361"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <dc:creator>Boehmer, Harald von</dc:creator> <dcterms:abstract xml:lang="eng">Transfected T cell receptor (TCR) beta chain genes are expressed as homodimers on the surface of immature (Sci/ET27F) but not on mature (58 alpha-beta-) T cell lines which lack TCR alpha, gamma and delta chains. The homodimer on Sci/ET27F cells is tightly bound to CD3 delta and CD3 epsilon while the association with CD3 gamma and CD3 zeta proteins is rather weak. Crosslinking of the TCR beta homodimers resulted in a strong and rapid calcium flux. In 58 alpha-beta- T cells the beta TCR chain could be easily visualized intracellularly but was not transported to the cell surface. The Scid cell lines considerably facilitate the molecular analysis of early differentiation events in the thymus which are likely to be regulated by the beta TCR homodimer.</dcterms:abstract> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:rights>terms-of-use</dc:rights> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Gröttrup, Marcus</dc:creator> <dc:contributor>Baron, Agnes</dc:contributor> <dc:contributor>Palacios, Ronald</dc:contributor> <dcterms:issued>1992</dcterms:issued> <dc:creator>Palacios, Ronald</dc:creator> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:creator>Baron, Agnes</dc:creator> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


Browse

My Account