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A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation

A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation

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OSSENDORP, Ferry, Maren EGGERS, Anne NEISIG, Thomas RUPPERT, Marcus GRÖTTRUP, Alice SIJTS, Erica MENGEDÉ, Peter-Michael KLOETZEL, Jacques NEEFJES, Ulrich KOSZINOWSKI, Cornelis MELIEF, 1996. A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation. In: Immunity. 5(2), pp. 115-124. ISSN 1074-7613. eISSN 1097-4180

@article{Ossendorp1996singl-22317, title={A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation}, year={1996}, doi={10.1016/S1074-7613(00)80488-4}, number={2}, volume={5}, issn={1074-7613}, journal={Immunity}, pages={115--124}, author={Ossendorp, Ferry and Eggers, Maren and Neisig, Anne and Ruppert, Thomas and Gröttrup, Marcus and Sijts, Alice and Mengedé, Erica and Kloetzel, Peter-Michael and Neefjes, Jacques and Koszinowski, Ulrich and Melief, Cornelis} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/22317"> <dc:creator>Neefjes, Jacques</dc:creator> <dc:creator>Koszinowski, Ulrich</dc:creator> <dc:creator>Mengedé, Erica</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-07T10:00:00Z</dcterms:available> <dc:language>eng</dc:language> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:contributor>Neisig, Anne</dc:contributor> <dc:contributor>Sijts, Alice</dc:contributor> <dc:contributor>Ossendorp, Ferry</dc:contributor> <dc:creator>Ossendorp, Ferry</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-07T10:00:00Z</dc:date> <dc:contributor>Kloetzel, Peter-Michael</dc:contributor> <dcterms:abstract xml:lang="eng">CTL epitope (KSPWFTTL) encoded by AKV/MCF type of murine leukemia virus (MuLV) differs from the sequence in Friend/Moloney/Rauscher (FMR) type in one residue (RSPWFTTL). CTL experiments indicated defective processing of the FMR peptide in tumor cells. Proteasome-mediated digestion of AKV/MCF-type 26-mer peptides resulted in the early generation and higher levels of epitope-containing fragments than digestion of FMR-type peptides, explained by prominent cleavage next to R in the FMR sequence. The fragments were identified as 10- and 11-mer peptides and were efficiently translocated by TAP. The naturally presented AKV/MCF peptide is the 8-mer, indicating ER peptide trimming. In conclusion, a single residue exchange can cause CTL epitope destruction by specific proteasomal cleavage.</dcterms:abstract> <dc:contributor>Koszinowski, Ulrich</dc:contributor> <dc:creator>Gröttrup, Marcus</dc:creator> <dcterms:title>A single residue exchange within a viral CTL epitope alters proteasome-mediated degradation resulting in lack of antigen presentation</dcterms:title> <dc:rights>deposit-license</dc:rights> <dc:creator>Kloetzel, Peter-Michael</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22317"/> <dc:contributor>Melief, Cornelis</dc:contributor> <dc:contributor>Neefjes, Jacques</dc:contributor> <dc:contributor>Mengedé, Erica</dc:contributor> <dc:creator>Sijts, Alice</dc:creator> <dc:creator>Ruppert, Thomas</dc:creator> <dc:contributor>Eggers, Maren</dc:contributor> <dc:contributor>Ruppert, Thomas</dc:contributor> <dc:creator>Melief, Cornelis</dc:creator> <dcterms:issued>1996</dcterms:issued> <dc:creator>Eggers, Maren</dc:creator> <dc:creator>Neisig, Anne</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:bibliographicCitation>Immunity ; 5 (1996), 2. - S. 115-124</dcterms:bibliographicCitation> </rdf:Description> </rdf:RDF>

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