Type of Publication: | Journal article |
Author: | Gröttrup, Marcus; Schmidtke, Gunter |
Year of publication: | 1999 |
Published in: | Schweizerische Medizinische Wochenschrift ; 129 (1999), 44. - pp. 1660-1665. - ISSN 0036-7672 |
Title in another language: | Die intrazelluläre Prozessierung von Virus- und Tumorantigenen durch das Proteasom |
Summary: |
Cytotoxic T cells are able to recognise whether a cell of our body is infected by a virus or whether it has acquired mutations leading to tumour formation. The cells show on their surface what kind of proteins are synthesised intracellularly and whether non-self proteins encoded by a virus or tumour antigens are among them. The proteins are presented not as functionally intact proteins but as peptide fragments which originate from their regular intracellular degradation. This fragmentation is accomplished by the proteasome, a large proteinase complex in the cytoplasm and nucleus of all cells. Upon stimulation with the antiviral cytokine interferon-gamma, subunits of the proteasome are exchanged, thus leading to optimised production of peptide antigens. In this review we introduce the system of antigen processing by the proteasome and sum up our latest results on the question how the interferon-gamma-mediated reorganisation of the proteasome occurs and what consequences and benefits this has for the cytotoxic immune response against viruses and tumours.
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Summary in another language: |
Zytotoxische T-Zellen können von aussen erkennen, ob eine Zelle unseres Körpers mit einem Virus infiziert ist oder ob sie zu einer Tumorzelle entartet ist. Die Zellen unseres Körpers zeigen auf ihrer Oberfläche, welche Proteine in der Zelle gemacht werden und ob Fremdproteine von einem Virus oder Tumorantigene darunter sind. Die Proteine werden nicht als intakte, funktionell aktive Proteine präsentiert, sondern als Peptidfragmente, die aus ihrem intrazellulären Abbau entstehen. Dieser Abbau erfolgt durch das Proteasom, einen grossen Proteinasekomplex im Zytoplasma und im Kern einer jeden Zelle. Die Stimulation von Zellen mit dem antiviralen Zytokin Interferon-γ führt dazu, dass Untereinheiten des Proteasoms ausgetauscht werden, was eine Optimierung der Produktion von Peptidantigenen zur Folge hat. In diesem Artikel stellen wir das System der Antigenprozessierung durch das Proteasom vor und berichten von unseren Ergebnissen zu der Frage, wie das Proteasom durch das antivirale Zytokin Interferon-γ strukturell verändert wird und wie dies zum Erfolg der zytotoxischen
Immunantwort gegen Viren oder Tumoren beiträgt. |
Subject (DDC): | 570 Biosciences, Biology |
Keywords: | proteasome, MHC class I, antigen presentation, interferon-gamma |
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GRÖTTRUP, Marcus, Gunter SCHMIDTKE, 1999. Intracellular processing of viral and tumor antigens by proteasomes. In: Schweizerische Medizinische Wochenschrift. 129(44), pp. 1660-1665. ISSN 0036-7672
@article{Grottrup1999Intra-22235, title={Intracellular processing of viral and tumor antigens by proteasomes}, year={1999}, number={44}, volume={129}, issn={0036-7672}, journal={Schweizerische Medizinische Wochenschrift}, pages={1660--1665}, author={Gröttrup, Marcus and Schmidtke, Gunter} }
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