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Efficient presentation of exogenous antigen by liver endothelial cells to CD8<sup>+</sup> T cells results in antigen-specific T-cell tolerance

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

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Prüfsumme: MD5:eb1739b35c3ddb10777b5e8fafdec257

LIMMER, Andreas, Jutta OHL, Christian KURTS, Hans-Gustaf LJUNGGREN, Yuval REISS, Marcus GRÖTTRUP, Frank MOMBURG, Bernd ARNOLD, Percy A. KNOLLE, 2000. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. In: Nature Medicine. 6(12), pp. 1348-1354. ISSN 1078-8956. eISSN 1546-170X. Available under: doi: 10.1038/82161

@article{Limmer2000-12Effic-22162, title={Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance}, year={2000}, doi={10.1038/82161}, number={12}, volume={6}, issn={1078-8956}, journal={Nature Medicine}, pages={1348--1354}, author={Limmer, Andreas and Ohl, Jutta and Kurts, Christian and Ljunggren, Hans-Gustaf and Reiss, Yuval and Gröttrup, Marcus and Momburg, Frank and Arnold, Bernd and Knolle, Percy A.} }

Momburg, Frank Nature Medicine ; 6 (2000), 12. - S. 1348-1354 Limmer, Andreas Ohl, Jutta eng Gröttrup, Marcus Efficient presentation of exogenous antigen by liver endothelial cells to CD8<sup>+</sup> T cells results in antigen-specific T-cell tolerance Myeloid antigen-presenting cells (APC) are known to cross-present exogenous antigen on major histocompatibility class I molecules to CD8+ T cells and thereby induce protective immunity against infecting microorganisms. Here we report that liver sinusoidal endothelial cells (LSEC) are organ-resident, non-myeloid APC capable of cross-presenting soluble exogenous antigen to CD8+ T cells. Though LSEC employ similar molecular mechanisms for cross-presentation as dendritic cells, the outcome of cross-presentation by LSEC is CD8+ T cell tolerance rather than immunity. As uptake of circulating antigens into LSEC occurs efficiently in vivo, it is likely that cross-presentation by LSEC contributes to CD8+ T cell tolerance observed in situations where soluble antigen is present in the circulation. Limmer, Andreas Momburg, Frank Knolle, Percy A. Kurts, Christian Knolle, Percy A. Reiss, Yuval Arnold, Bernd Ohl, Jutta Arnold, Bernd Gröttrup, Marcus 2013-03-22T09:52:51Z terms-of-use Kurts, Christian 2000-12 2013-03-22T09:52:51Z Reiss, Yuval Ljunggren, Hans-Gustaf Ljunggren, Hans-Gustaf

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