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Efficient presentation of exogenous antigen by liver endothelial cells to CD8<sup>+</sup> T cells results in antigen-specific T-cell tolerance

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

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LIMMER, Andreas, Jutta OHL, Christian KURTS, Hans-Gustaf LJUNGGREN, Yuval REISS, Marcus GRÖTTRUP, Frank MOMBURG, Bernd ARNOLD, Percy A. KNOLLE, 2000. Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance. In: Nature Medicine. 6(12), pp. 1348-1354. ISSN 1078-8956. eISSN 1546-170X. Available under: doi: 10.1038/82161

@article{Limmer2000-12Effic-22162, title={Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance}, year={2000}, doi={10.1038/82161}, number={12}, volume={6}, issn={1078-8956}, journal={Nature Medicine}, pages={1348--1354}, author={Limmer, Andreas and Ohl, Jutta and Kurts, Christian and Ljunggren, Hans-Gustaf and Reiss, Yuval and Gröttrup, Marcus and Momburg, Frank and Arnold, Bernd and Knolle, Percy A.} }

Momburg, Frank Nature Medicine ; 6 (2000), 12. - S. 1348-1354 Limmer, Andreas Ohl, Jutta eng Gröttrup, Marcus Efficient presentation of exogenous antigen by liver endothelial cells to CD8<sup>+</sup> T cells results in antigen-specific T-cell tolerance Myeloid antigen-presenting cells (APC) are known to cross-present exogenous antigen on major histocompatibility class I molecules to CD8+ T cells and thereby induce protective immunity against infecting microorganisms. Here we report that liver sinusoidal endothelial cells (LSEC) are organ-resident, non-myeloid APC capable of cross-presenting soluble exogenous antigen to CD8+ T cells. Though LSEC employ similar molecular mechanisms for cross-presentation as dendritic cells, the outcome of cross-presentation by LSEC is CD8+ T cell tolerance rather than immunity. As uptake of circulating antigens into LSEC occurs efficiently in vivo, it is likely that cross-presentation by LSEC contributes to CD8+ T cell tolerance observed in situations where soluble antigen is present in the circulation. Limmer, Andreas Momburg, Frank Knolle, Percy A. Kurts, Christian deposit-license Knolle, Percy A. Reiss, Yuval Arnold, Bernd Ohl, Jutta Arnold, Bernd 2013-03-22T09:52:51Z Gröttrup, Marcus Kurts, Christian 2000-12 2013-03-22T09:52:51Z Reiss, Yuval Ljunggren, Hans-Gustaf Ljunggren, Hans-Gustaf

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