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Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro

Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro

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AUDRAN, Régine, Katrin PETER, Jens DANNULL, Ying MEN, Elke SCANDELLA, Marcus GRÖTTRUP, Bruno GANDER, Giampietro CORRADIN, 2003. Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro. In: Vaccine. 21(11-12), pp. 1250-1255. ISSN 0264-410X. eISSN 1873-2518

@article{Audran2003Encap-22136, title={Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro}, year={2003}, doi={10.1016/S0264-410X(02)00521-2}, number={11-12}, volume={21}, issn={0264-410X}, journal={Vaccine}, pages={1250--1255}, author={Audran, Régine and Peter, Katrin and Dannull, Jens and Men, Ying and Scandella, Elke and Gröttrup, Marcus and Gander, Bruno and Corradin, Giampietro} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/22136"> <dc:language>eng</dc:language> <dc:rights>deposit-license</dc:rights> <dc:creator>Scandella, Elke</dc:creator> <dc:creator>Corradin, Giampietro</dc:creator> <dc:creator>Gröttrup, Marcus</dc:creator> <dc:creator>Peter, Katrin</dc:creator> <dc:creator>Men, Ying</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-25T13:48:15Z</dc:date> <dcterms:issued>2003</dcterms:issued> <dc:contributor>Corradin, Giampietro</dc:contributor> <dc:contributor>Dannull, Jens</dc:contributor> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-25T13:48:15Z</dcterms:available> <dc:contributor>Scandella, Elke</dc:contributor> <dc:contributor>Audran, Régine</dc:contributor> <dc:creator>Dannull, Jens</dc:creator> <dcterms:title>Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro</dcterms:title> <dc:creator>Audran, Régine</dc:creator> <dcterms:bibliographicCitation>Vaccine ; 21 (2003), 11-12. - S. 1250-1255</dcterms:bibliographicCitation> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22136"/> <dcterms:abstract xml:lang="eng">Biodegradable microspheres (MS) consisting of poly(D,L-lactide-co-glycolide) (PLGA) represent a promising alternative to conventional adjuvants. The adjustable pulsatile release of encapsulated material from such MS offers the potential to mimic the priming and boosting injections of conventional immunization regimens. In this paper, we demonstrate that MS can serve as antigen reservoirs in antigen presenting cells (APC), so that antigen is presented for extended periods of time (up to 9 days). In particular, we could show by measurement of IFN-gamma production that encapsulated peptides were presented to cytotoxic T lymphocytes (CTL) by mouse and human macrophages as well as by human dendritic cells in vitro for a longer time period as compared to soluble peptides. The extended antigen presentation may thus improve the CTL response in vivo. These results may be of paramount importance in cancer vaccination therapy since MS may serve as antigen reservoirs to extend the presentation time by APC used to boost the patient's immune response to tumor antigens.</dcterms:abstract> <dc:creator>Gander, Bruno</dc:creator> <dc:contributor>Men, Ying</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Gander, Bruno</dc:contributor> <dc:contributor>Peter, Katrin</dc:contributor> </rdf:Description> </rdf:RDF>

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