Delivery of Tumor Antigens to Dendritic Cells Using Biodegradable Microspheres


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WAECKERLE-MEN, Ying, Bruno GANDER, Marcus GRÖTTRUP, 2004. Delivery of Tumor Antigens to Dendritic Cells Using Biodegradable Microspheres. In: LUDEWIG, Burkhard, Matthias W. HOFFMANN. Adoptive Immunotherapy : Methods and Protocols. Totowa, NJ:Humana Press, pp. 035-046. ISBN 978-1-58829-406-7. Available under: doi: 10.1385/1-59259-862-5:035

@incollection{WaeckerleMen2004Deliv-22120, title={Delivery of Tumor Antigens to Dendritic Cells Using Biodegradable Microspheres}, year={2004}, doi={10.1385/1-59259-862-5:035}, number={109}, isbn={978-1-58829-406-7}, address={Totowa, NJ}, publisher={Humana Press}, series={Methods in Molecular Medicine}, booktitle={Adoptive Immunotherapy : Methods and Protocols}, pages={035--046}, author={Waeckerle-Men, Ying and Gander, Bruno and Gröttrup, Marcus} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:available rdf:datatype="">2013-03-22T09:57:59Z</dcterms:available> <dcterms:rights rdf:resource=""/> <dc:contributor>Waeckerle-Men, Ying</dc:contributor> <dc:contributor>Gander, Bruno</dc:contributor> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:creator>Waeckerle-Men, Ying</dc:creator> <dcterms:isPartOf rdf:resource=""/> <bibo:uri rdf:resource=""/> <dc:creator>Gröttrup, Marcus</dc:creator> <dc:creator>Gander, Bruno</dc:creator> <dcterms:bibliographicCitation>Adoptive Immunotherapy : Methods and Protocols / ed. by Burkhard Ludewig ... - Totowa, NJ : Humana Press, 2005. - S. 35-46. - (Methods in Molecular Medicine ; 109). - ISBN 978-1-58829-406-7</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dcterms:issued>2004</dcterms:issued> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:date rdf:datatype="">2013-03-22T09:57:59Z</dc:date> <dcterms:title>Delivery of Tumor Antigens to Dendritic Cells Using Biodegradable Microspheres</dcterms:title> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">Poly(D,L-lactide-co-glycolide) (PLGA) polymers have been used for the production of biodegradable medical sutures and for controlled drug release for decades. Useful characteristics such as in vivo biodegradability, an adjustable release profile, and the very high encapsulation capacity have stimulated immunologists to explore PLGA microspheres (MS) as antigen delivery systems for vaccination for more than 15 yr. In previous studies aiming at the development of "single-dose" vaccines, direct immunization with PLGA MS containing various antigens induced strong and sustained immune responses. We have observed that human immature monocyte-derived dendritic cells (MoDC) prepared for clinical application are able to internalize high numbers of MS without negative effects on their pivotal properties. Furthermore, PLGA-MS-incorporated antigens are effectively processed for presentation on Major histocompatibility complex (MHC) class I and MHC class II molecules by dendritic cells (DCs) in vitro and induced strong cytotoxic T-lymphocyte (CTL) responses in vivo. Taken together, PLGA MS is a promising delivery vehicle for the improvement of current DC-based tumor vaccine protocols.</dcterms:abstract> <dc:rights>terms-of-use</dc:rights> <dspace:isPartOfCollection rdf:resource=""/> </rdf:Description> </rdf:RDF>

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