Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-221197 |
Author: | Waeckerle-Men, Ying; Uetz-von Allmen, Edith; Moos, Roger von; Classon, Brendan J.; Scandella, Elke; Schmid, Hans-Peter; Ludewig, Burkhard; Gröttrup, Marcus; Gillessen, Silke |
Year of publication: | 2005 |
Published in: | The Prostate ; 64 (2005), 4. - pp. 323-331. - ISSN 0270-4137. - eISSN 1097-0045 |
Pubmed ID: | 15754347 |
DOI (citable link): | https://dx.doi.org/10.1002/pros.20231 |
Summary: |
BACKGROUND Dendritic cell (DC)-based vaccination has been investigated as immunotherapy for several types of cancer. A potential drawback to vaccination with autologous monocyte-derived DCs (MoDCs) could be that MoDCs from patients are functionally impaired. In case of androgen-independent prostate cancer (CaP), the cancer itself, diverse prior therapies, and the hormone manipulation may affect the immune system.
METHODS. MoDCs from patients suffering from androgen-independent CaP were generated according to a clinically applicable protocol to evaluate the phenotype, maturation capacity, migration, and T-cell stimulation of these cells compared with those generated from tumor-free donors. RESULTS MoDCs generated from CaP patients could be fully matured and efficiently migrated towards the chemokine CCL21. They had a strong potency to activate allogeneicCD4þ and CD8þ T-cells and to present antigens to specific CTL. CONCLUSIONS Our data suggest that MoDCs from patients with androgen-independent CaP are functionally intact and hence qualify as cellular vaccines for immunotherapy of advanced stage CaP. |
Subject (DDC): | 570 Biosciences, Biology |
Keywords: | prostate cancer, cancer vaccine, monocyte-derived dendritic cells (MoDCs), DC phenotype and functions |
Link to License: | In Copyright |
Bibliography of Konstanz: | Yes |
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WAECKERLE-MEN, Ying, Edith UETZ-VON ALLMEN, Roger von MOOS, Brendan J. CLASSON, Elke SCANDELLA, Hans-Peter SCHMID, Burkhard LUDEWIG, Marcus GRÖTTRUP, Silke GILLESSEN, 2005. Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation. In: The Prostate. 64(4), pp. 323-331. ISSN 0270-4137. eISSN 1097-0045. Available under: doi: 10.1002/pros.20231
@article{WaeckerleMen2005-09-01Dendr-22119, title={Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation}, year={2005}, doi={10.1002/pros.20231}, number={4}, volume={64}, issn={0270-4137}, journal={The Prostate}, pages={323--331}, author={Waeckerle-Men, Ying and Uetz-von Allmen, Edith and Moos, Roger von and Classon, Brendan J. and Scandella, Elke and Schmid, Hans-Peter and Ludewig, Burkhard and Gröttrup, Marcus and Gillessen, Silke} }
Waeckerle-Men_221197.pdf | 137 |