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Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation

Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation

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WAECKERLE-MEN, Ying, Edith UETZ-VON ALLMEN, Roger von MOOS, Brendan J. CLASSON, Elke SCANDELLA, Hans-Peter SCHMID, Burkhard LUDEWIG, Marcus GRÖTTRUP, Silke GILLESSEN, 2005. Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation. In: The Prostate. 64(4), pp. 323-331. ISSN 0270-4137. eISSN 1097-0045

@article{Waeckerle-Men2005-09-01Dendr-22119, title={Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation}, year={2005}, doi={10.1002/pros.20231}, number={4}, volume={64}, issn={0270-4137}, journal={The Prostate}, pages={323--331}, author={Waeckerle-Men, Ying and Uetz-von Allmen, Edith and Moos, Roger von and Classon, Brendan J. and Scandella, Elke and Schmid, Hans-Peter and Ludewig, Burkhard and Gröttrup, Marcus and Gillessen, Silke} }

Scandella, Elke Gröttrup, Marcus Classon, Brendan J. Dendritic Cells Generated From Patients With Androgen-Independent Prostate Cancer Are Not Impaired in Migration and T-Cell Stimulation Waeckerle-Men, Ying Waeckerle-Men, Ying The Prostate ; 64 (2005), 4. - S. 323-331 2005-09-01 BACKGROUND<br />Dendritic cell (DC)-based vaccination has been investigated as immunotherapy for several types of cancer. A potential drawback to vaccination with autologous monocyte-derived DCs (MoDCs) could be that MoDCs from patients are functionally impaired. In case of androgen-independent prostate cancer (CaP), the cancer itself, diverse prior therapies, and the hormone manipulation may affect the immune system.<br />METHODS. MoDCs from patients suffering from androgen-independent CaP were generated<br />according to a clinically applicable protocol to evaluate the phenotype, maturation capacity,<br />migration, and T-cell stimulation of these cells compared with those generated from tumor-free<br />donors.<br /><br /><br />RESULTS<br />MoDCs generated from CaP patients could be fully matured and efficiently<br />migrated towards the chemokine CCL21. They had a strong potency to activate allogeneicCD4þ<br />and CD8þ T-cells and to present antigens to specific CTL.<br /><br /><br />CONCLUSIONS<br />Our data suggest that MoDCs from patients with androgen-independent<br />CaP are functionally intact and hence qualify as cellular vaccines for immunotherapy of advanced stage CaP. eng Gillessen, Silke Moos, Roger von Moos, Roger von Schmid, Hans-Peter 2013-02-26T08:57:04Z 2013-02-26T08:57:04Z Gillessen, Silke Gröttrup, Marcus Uetz-von Allmen, Edith Schmid, Hans-Peter Uetz-von Allmen, Edith Ludewig, Burkhard Classon, Brendan J. deposit-license Scandella, Elke Ludewig, Burkhard

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