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Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells

Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells

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WAECKERLE-MEN, Ying, Edith UETZ-VON ALLMEN, Bruno GANDER, Elke SCANDELLA, Eva SCHLOSSER, Gunter SCHMIDTKE, Hans P. MERKLE, Marcus GRÖTTRUP, 2006. Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells. In: Vaccine. 24(11), pp. 1847-1857. ISSN 0264-410X. eISSN 1873-2518

@article{Waeckerle-Men2006-03-10Encap-22117, title={Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells}, year={2006}, doi={10.1016/j.vaccine.2005.10.032}, number={11}, volume={24}, issn={0264-410X}, journal={Vaccine}, pages={1847--1857}, author={Waeckerle-Men, Ying and Uetz-von Allmen, Edith and Gander, Bruno and Scandella, Elke and Schlosser, Eva and Schmidtke, Gunter and Merkle, Hans P. and Gröttrup, Marcus} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/22117"> <dc:creator>Waeckerle-Men, Ying</dc:creator> <dc:creator>Scandella, Elke</dc:creator> <dc:creator>Gröttrup, Marcus</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:contributor>Scandella, Elke</dc:contributor> <dcterms:issued>2006-03-10</dcterms:issued> <dc:language>eng</dc:language> <dc:contributor>Waeckerle-Men, Ying</dc:contributor> <dc:contributor>Schlosser, Eva</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-06T11:06:14Z</dc:date> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22117"/> <dc:contributor>Gander, Bruno</dc:contributor> <dc:creator>Schlosser, Eva</dc:creator> <dcterms:bibliographicCitation>Vaccine ; 24 (2006), 11. - S. 1847-1857</dcterms:bibliographicCitation> <dc:contributor>Schmidtke, Gunter</dc:contributor> <dc:creator>Schmidtke, Gunter</dc:creator> <dc:creator>Gander, Bruno</dc:creator> <dc:contributor>Merkle, Hans P.</dc:contributor> <dc:creator>Uetz-von Allmen, Edith</dc:creator> <dc:creator>Merkle, Hans P.</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:contributor>Uetz-von Allmen, Edith</dc:contributor> <dcterms:title>Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells</dcterms:title> <dcterms:abstract xml:lang="eng">Dendritic cell (DC)-based immunotherapy has been hampered by the lack of suitable methods for antigen delivery. Here, we use biodegradable poly(d,l-lactide-co-glycolide) microspheres (PLGA-MS) as carriers of peptides and proteins for antigen delivery to human monocyte-derived DC (MoDC). Compared to soluble proteins, MHC classes I and II-restricted presentation of PLGA-MS-encapsulated proteins and peptides by MoDC was markedly prolonged and proteins were presented 50-fold more efficiently on class I molecules. The vaccination of mice with DC loaded with PLGA-MS-encapsulated proteins raised strong and persisting cytotoxic T cell responses. In conclusion, antigen delivery via PLGA-MS markedly enhanced the duration of antigen presentation by human MoDC and the potency of DC-based vaccination.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-06T11:06:14Z</dcterms:available> </rdf:Description> </rdf:RDF>

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