An altered T cell repertoire in MECL-1-deficient mice

Type of Publication: Journal article
Author: Basler, Michael; Moebius, Jacqueline; Elenich, Laura; Gröttrup, Marcus; Monaco, John J.
Year of publication: 2006
Published in: The journal of immunology ; 176 (2006), 11. - pp. 6665-6672. - ISSN 0022-1767. - eISSN 1550-6606
DOI (citable link): https://dx.doi.org/10.4049/jimmunol.176.11.6665
Summary:
Immunoproteasome subunits low-molecular mass polypeptide (LMP)2 and LMP7 affect Ag presentation by MHC class I molecules.
In the present study, we investigated the function of the third immunosubunit LMP10/multicatalytic endopeptidase complexlike (MECL)-1 ( 2i) in MECL-1 gene-targeted mice. The number of CD8 splenocytes in MECL-1 / mice was 20% lower than in wild-type mice. Infection with lymphocytic choriomeningitis virus (LCMV) elicited a markedly reduced cytotoxic T cell (CTL) response to the LCMV epitopes GP276–286/Db and NP205–212/Kb in MECL-1 / mice. The weak CTL response to GP276–286/Db was not due to an impaired generation of this epitope but was attributed to a decreased precursor frequency of GP276–286/Db-specific T cells. The expansion of TCR-V 10 T cells, which contain GP276–286/Db-specific cells, was reduced in LCMVinfected MECL-1 / mice. Taken together, our data reveal an in vivo function of MECL-1 in codetermining the T cell repertoire for an antiviral CTL response.
Subject (DDC): 570 Biosciences, Biology
Bibliography of Konstanz: Yes

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BASLER, Michael, Jacqueline MOEBIUS, Laura ELENICH, Marcus GRÖTTRUP, John J. MONACO, 2006. An altered T cell repertoire in MECL-1-deficient mice. In: The journal of immunology. 176(11), pp. 6665-6672. ISSN 0022-1767. eISSN 1550-6606. Available under: doi: 10.4049/jimmunol.176.11.6665

@article{Basler2006alter-22112, title={An altered T cell repertoire in MECL-1-deficient mice}, year={2006}, doi={10.4049/jimmunol.176.11.6665}, number={11}, volume={176}, issn={0022-1767}, journal={The journal of immunology}, pages={6665--6672}, author={Basler, Michael and Moebius, Jacqueline and Elenich, Laura and Gröttrup, Marcus and Monaco, John J.} }

Basler, Michael Monaco, John J. Gröttrup, Marcus An altered T cell repertoire in MECL-1-deficient mice Elenich, Laura 2013-03-07T10:22:09Z Immunoproteasome subunits low-molecular mass polypeptide (LMP)2 and LMP7 affect Ag presentation by MHC class I molecules.<br />In the present study, we investigated the function of the third immunosubunit LMP10/multicatalytic endopeptidase complexlike (MECL)-1 ( 2i) in MECL-1 gene-targeted mice. The number of CD8 splenocytes in MECL-1 / mice was 20% lower than in wild-type mice. Infection with lymphocytic choriomeningitis virus (LCMV) elicited a markedly reduced cytotoxic T cell (CTL) response to the LCMV epitopes GP276–286/Db and NP205–212/Kb in MECL-1 / mice. The weak CTL response to GP276–286/Db was not due to an impaired generation of this epitope but was attributed to a decreased precursor frequency of GP276–286/Db-specific T cells. The expansion of TCR-V 10 T cells, which contain GP276–286/Db-specific cells, was reduced in LCMVinfected MECL-1 / mice. Taken together, our data reveal an in vivo function of MECL-1 in codetermining the T cell repertoire for an antiviral CTL response. 2013-03-07T10:22:09Z eng Moebius, Jacqueline 2006 Gröttrup, Marcus Basler, Michael terms-of-use Monaco, John J. The journal of immunology ; 176 (2006), 11. - S. 6665-6672 Moebius, Jacqueline Elenich, Laura

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