Immunoproteasome-Specific Inhibitors and Their Application

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BASLER, Michael, Marcus GRÖTTRUP, 2012. Immunoproteasome-Specific Inhibitors and Their Application. In: DOHMEN, R. Jürgen, ed., Martin SCHEFFNER, ed.. Ubiquitin Family Modifiers and the Proteasome. Totowa, NJ:Humana Press, pp. 391-401. ISBN 978-1-61779-473-5

@incollection{Basler2012Immun-22002, title={Immunoproteasome-Specific Inhibitors and Their Application}, year={2012}, doi={10.1007/978-1-61779-474-2_27}, number={832}, isbn={978-1-61779-473-5}, address={Totowa, NJ}, publisher={Humana Press}, series={Methods in Molecular Biology}, booktitle={Ubiquitin Family Modifiers and the Proteasome}, pages={391--401}, editor={Dohmen, R. Jürgen and Scheffner, Martin}, author={Basler, Michael and Gröttrup, Marcus} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/22002"> <dcterms:issued>2012</dcterms:issued> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:creator>Basler, Michael</dc:creator> <dc:rights>deposit-license</dc:rights> <dcterms:bibliographicCitation>Ubiquitin family modifiers and the proteasome : reviews and protocols / ed. by R. Jürgen Dohmen ... - New York, NY; Heidelberg [u.a.] : Humana Press, 2012. - S. 391-401. - (Methods in molecular biology ; 832). - ISBN 978-1-617-79473-5</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-12T10:23:19Z</dc:date> <dc:creator>Gröttrup, Marcus</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/22002"/> <dc:contributor>Basler, Michael</dc:contributor> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-12T10:23:19Z</dcterms:available> <dcterms:title>Immunoproteasome-Specific Inhibitors and Their Application</dcterms:title> <dcterms:abstract xml:lang="eng">Immunoproteasomes (IPs) containing the interferon-inducible subunits beta1i (LMP2), beta2i (MECL-1), and beta5i (LMP7) alter proteasomal cleavage preference, optimise the generation of peptide ligands of MHC class I molecules, alter cytokine profile, influence T-helper cell differentiation, and play a role in T-cell survival. Small molecule inhibitors are useful tools for probing the role of the immunoproteasome in immune functions. Here, we describe different methods to characterise immunoproteasome-selective inhibitors. Thereby, we provide the methodology to analyse the specificity and cell permeability of immunoproteasome inhibitors, as well as to functionally investigate immunoproteasome inhibitors in antigen presentation.</dcterms:abstract> </rdf:Description> </rdf:RDF>

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