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Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit

Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit

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KALIM, Khalid W., Marcus GRÖTTRUP, 2013. Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit. In: Molecular Immunology. 53(3), pp. 274-282. ISSN 0161-5890. eISSN 1872-9142

@article{Kalim2013-03Prost-21990, title={Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit}, year={2013}, doi={10.1016/j.molimm.2012.08.014}, number={3}, volume={53}, issn={0161-5890}, journal={Molecular Immunology}, pages={274--282}, author={Kalim, Khalid W. and Gröttrup, Marcus} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/21990"> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/21990"/> <dc:creator>Kalim, Khalid W.</dc:creator> <dcterms:issued>2013-03</dcterms:issued> <dc:rights>deposit-license</dc:rights> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-20T10:40:43Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-20T10:40:43Z</dc:date> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:bibliographicCitation>Molecular Immunology ; 53 (2013), 3. - S. 274-282</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dc:contributor>Kalim, Khalid W.</dc:contributor> <dcterms:abstract xml:lang="eng">The heterodimeric cytokine IL-23 is important for the maintenance of Th17 cells, which are pivotal mediators of autoimmune diseases like rheumatoid arthritis, colitis, and multiple sclerosis. Prostaglandin E2 (PGE2) is a soluble regulator of inflammation that has both pro- and anti-inflammatory properties. PGE2 has been shown to elevate the IL-23 production by dendritic cells (DC). Monocytes are also producers of IL-23 but the effect of PGE2 on IL-23 production by human monocytes has hardly been investigated. We show here that PGE2 blocks the production of IL-23 by LPS-stimulated monocytes in an IL-10 and IL-1 independent manner. This effect was due to the down-regulation of the p40 subunit of IL-23 on mRNA and protein level. The p40 subunit is shared by IL-12 and, consistently, PGE2 also lowered the IL-12 production by monocytes. These effects of PGE2 were cAMP-dependent since the cAMP enhancer forskolin strongly reduced IL-23 and IL-12 production by monocytes. Taken together, PGE2 acts in an anti-inflammatory manner by lowering IL-23 production by monocytes while it has the opposite effect in DC. Our data may help to reconcile controversial point of views on the pro- and anti-inflammatory nature of PGE2 by making a strong case for a cell type-dependent function.</dcterms:abstract> <dc:creator>Gröttrup, Marcus</dc:creator> <dcterms:title>Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit</dcterms:title> <dc:contributor>Gröttrup, Marcus</dc:contributor> </rdf:Description> </rdf:RDF>

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