The immunoproteasome in antigen processing and other immunological functions


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BASLER, Michael, Christopher J. KIRK, Marcus GRÖTTRUP, 2013. The immunoproteasome in antigen processing and other immunological functions. In: Current Opinion in Immunology. 25(1), pp. 74-80. ISSN 0952-7915. eISSN 1879-0372

@article{Basler2013-02immun-21986, title={The immunoproteasome in antigen processing and other immunological functions}, year={2013}, doi={10.1016/j.coi.2012.11.004}, number={1}, volume={25}, issn={0952-7915}, journal={Current Opinion in Immunology}, pages={74--80}, author={Basler, Michael and Kirk, Christopher J. and Gröttrup, Marcus} }

<rdf:RDF xmlns:rdf="" xmlns:bibo="" xmlns:dc="" xmlns:dcterms="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:rights>deposit-license</dc:rights> <dc:contributor>Kirk, Christopher J.</dc:contributor> <dcterms:abstract xml:lang="eng">Treatment of cells with interferon-g leads to the replacement of the constitutive catalytic proteasome subunits b1, b2, and b5 by the inducible subunits LMP2 (b1i), MECL-1 (b2i), and LMP7 (b5i), respectively, building the so-called immunoproteasome. The incorporation of these subunits is required for the production of numerous MHC class-I restricted T cell epitopes. Recently, new evidence for an involvement of the immunoproteasome in other facets of the immune response emerged. Investigations of autoimmune diseases in animal models and a genetic predisposition of b5i in human autoimmune disorders suggest a crucial function of the immunoproteasome in proinflammatory diseases. The recent elucidation of the high-resolution structure of the immunoproteasome will facilitate the design of immunoproteasome selective inhibitors for pharmacological intervention.</dcterms:abstract> <dcterms:available rdf:datatype="">2013-03-12T10:26:50Z</dcterms:available> <dcterms:rights rdf:resource=""/> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dc:creator>Kirk, Christopher J.</dc:creator> <dcterms:bibliographicCitation>Current Opinion in Immunology ; 25 (2013), 1. - S. 74-80</dcterms:bibliographicCitation> <dc:date rdf:datatype="">2013-03-12T10:26:50Z</dc:date> <bibo:uri rdf:resource=""/> <dc:creator>Gröttrup, Marcus</dc:creator> <dcterms:issued>2013-02</dcterms:issued> <dc:creator>Basler, Michael</dc:creator> <dcterms:title>The immunoproteasome in antigen processing and other immunological functions</dcterms:title> <dc:contributor>Basler, Michael</dc:contributor> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

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