Using protease inhibitors in antigen presentation assays

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BASLER, Michael, Marcus GRÖTTRUP, 2013. Using protease inhibitors in antigen presentation assays. In: VAN ENDERT, Peter, ed.. Antigen Processing. Totowa, NJ:Humana Press, pp. 31-39. ISBN 978-1-62703-217-9

@incollection{Basler2013Using-21985, title={Using protease inhibitors in antigen presentation assays}, year={2013}, doi={10.1007/978-1-62703-218-6_3}, number={960}, isbn={978-1-62703-217-9}, address={Totowa, NJ}, publisher={Humana Press}, series={Methods in Molecular Biology}, booktitle={Antigen Processing}, pages={31--39}, editor={van Endert, Peter}, author={Basler, Michael and Gröttrup, Marcus} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/21985"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-26T11:10:04Z</dc:date> <dc:rights>deposit-license</dc:rights> <dc:language>eng</dc:language> <dc:contributor>Basler, Michael</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/21985"/> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:abstract xml:lang="eng">The major histocompatibility complex (MHC) class I restricted pathway of antigen processing allows the presentation of intracellular antigens to cytotoxic T lymphocytes. The proteasome is the main protease in the cytoplasm and the nucleus, which is responsible for the generation of most peptide ligands of MHC-I molecules. Peptides produced by the proteasome can be further trimmed or destroyed by numerous cytosolic or endoplasmic reticulum (ER) lumenal proteases. Small molecule inhibitors are useful tools for probing the role of proteases in MHC class I antigen processing. Here, we describe different methods to test the impact of protease inhibitors in antigen presentation assays.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-26T11:10:04Z</dcterms:available> <dc:creator>Gröttrup, Marcus</dc:creator> <dcterms:issued>2013</dcterms:issued> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dcterms:title>Using protease inhibitors in antigen presentation assays</dcterms:title> <dcterms:bibliographicCitation>Antigen Processing : Methods and Protocols / ed. by Peter van Endert. - Totowa, NJ : Humana Press, 2012. - S. 31-39. - (Methods in Molecular Biology ; 960). - ISBN 978-1-627-03217-9</dcterms:bibliographicCitation> <dc:creator>Basler, Michael</dc:creator> </rdf:Description> </rdf:RDF>

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