Using protease inhibitors in antigen presentation assays

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

BASLER, Michael, Marcus GRÖTTRUP, 2013. Using protease inhibitors in antigen presentation assays. In: VAN ENDERT, Peter, ed.. Antigen Processing. Totowa, NJ:Humana Press, pp. 31-39. ISBN 978-1-62703-217-9. Available under: doi: 10.1007/978-1-62703-218-6_3

@incollection{Basler2013Using-21985, title={Using protease inhibitors in antigen presentation assays}, year={2013}, doi={10.1007/978-1-62703-218-6_3}, number={960}, isbn={978-1-62703-217-9}, address={Totowa, NJ}, publisher={Humana Press}, series={Methods in Molecular Biology}, booktitle={Antigen Processing}, pages={31--39}, editor={van Endert, Peter}, author={Basler, Michael and Gröttrup, Marcus} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:date rdf:datatype="">2013-02-26T11:10:04Z</dc:date> <dc:language>eng</dc:language> <dc:rights>terms-of-use</dc:rights> <dcterms:rights rdf:resource=""/> <dc:contributor>Basler, Michael</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <bibo:uri rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:abstract xml:lang="eng">The major histocompatibility complex (MHC) class I restricted pathway of antigen processing allows the presentation of intracellular antigens to cytotoxic T lymphocytes. The proteasome is the main protease in the cytoplasm and the nucleus, which is responsible for the generation of most peptide ligands of MHC-I molecules. Peptides produced by the proteasome can be further trimmed or destroyed by numerous cytosolic or endoplasmic reticulum (ER) lumenal proteases. Small molecule inhibitors are useful tools for probing the role of proteases in MHC class I antigen processing. Here, we describe different methods to test the impact of protease inhibitors in antigen presentation assays.</dcterms:abstract> <dcterms:available rdf:datatype="">2013-02-26T11:10:04Z</dcterms:available> <dc:creator>Gröttrup, Marcus</dc:creator> <dcterms:issued>2013</dcterms:issued> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dcterms:bibliographicCitation>Antigen Processing : Methods and Protocols / ed. by Peter van Endert. - Totowa, NJ : Humana Press, 2012. - S. 31-39. - (Methods in Molecular Biology ; 960). - ISBN 978-1-627-03217-9</dcterms:bibliographicCitation> <dcterms:title>Using protease inhibitors in antigen presentation assays</dcterms:title> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Basler, Michael</dc:creator> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


My Account