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Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

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Prüfsumme: MD5:0054550ccf3200bc28b488861fc925e2

GOLA, Hannah, Harald ENGLER, Annette SOMMERSHOF, Hannah ADENAUER, Stephan KOLASSA, Manfred SCHEDLOWSKI, Marcus GRÖTTRUP, Thomas ELBERT, Iris-Tatjana KOLASSA, 2013. Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. In: BMC Psychiatry. 13(1), 40. eISSN 1471-244X

@article{Gola2013Postt-21982, title={Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells}, year={2013}, doi={10.1186/1471-244X-13-40}, number={1}, volume={13}, journal={BMC Psychiatry}, author={Gola, Hannah and Engler, Harald and Sommershof, Annette and Adenauer, Hannah and Kolassa, Stephan and Schedlowski, Manfred and Gröttrup, Marcus and Elbert, Thomas and Kolassa, Iris-Tatjana}, note={Article Number: 40} }

2013 Sommershof, Annette Adenauer, Hannah Elbert, Thomas BMC Psychiatry ; 13 (2013), January. - 40 Kolassa, Stephan eng 2013-03-12T07:22:17Z Gröttrup, Marcus Gola, Hannah Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells Sommershof, Annette Adenauer, Hannah Engler, Harald 2013-03-12T07:22:17Z Schedlowski, Manfred Elbert, Thomas Kolassa, Stephan Gola, Hannah Gröttrup, Marcus Kolassa, Iris-Tatjana Engler, Harald deposit-license Schedlowski, Manfred Kolassa, Iris-Tatjana BACKGROUND<br />Posttraumatic stress disorder (PTSD) is associated with an enhanced risk for cardiovascular and other inflammatory diseases. Chronic low-level inflammation has been suggested as a potential mechanism linking these conditions. METHODS: We investigated plasma cytokine levels as well as spontaneous and lipopolysaccharide (LPS)-stimulated cytokine production by peripheral blood mononuclear cells (PBMCs) in a group of 35 severely traumatized PTSD patients compared to 25 healthy controls. RESULTS: Spontaneous production of interleukin (IL)-1beta, IL-6 and tumor necrosis factor (TNF)-alpha by isolated PBMCs was significantly higher in the PTSD compared to the control group and even correlated with PTSD symptom severity within the PTSD group. In contrast, circulating plasma levels of pro- and anti-inflammatory cytokines such as IL-6, IL-8, IL-10, TNF-alpha, or monocyte chemotactic protein (MCP)-1 were not significantly altered in PTSD patients compared to healthy controls.<br /><br />CONCLUSIONS<br />Our findings indicate that PBMCs of PTSD patients are already pre-activated in vivo, providing further evidence for low-grade inflammation in PTSD. This might possibly represent one psychobiological pathway from PTSD to poor physical health.

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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