Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation

Thumbnail Image
Date
2012
Authors
Meinzer, Marcus
Antonenko, Daria
Lindenberg, Robert
Hetzer, Stefan
Ulm, Lena
Avirame, Keren
Flöel, Agnes
Editors
Contact
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
URI (citable link)
ArXiv-ID
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Restricted until
Title in another language
Research Projects
Organizational Units
Journal Issue
Publication type
Journal article
Publication status
Published in
Journal of Neuroscience ; 32 (2012), 5. - pp. 1859-1866. - ISSN 0270-6474. - eISSN 1529-2401
Abstract
Excitatory anodal transcranial direct current stimulation (atDCS) can improve human cognitive functions, but neural underpinnings of its mode of action remain elusive. In a cross-over placebo ("sham") controlled study we used functional magnetic resonance imaging (fMRI) to investigate neurofunctional correlates of improved language functions induced by atDCS over a core language area, the left inferior frontal gyrus (IFG). Intrascanner transcranial direct current stimulation-induced changes in overt semantic word generation assessed behavioral modulation; task-related and task-independent (resting-state) fMRI characterized language network changes. Improved word-retrieval during atDCS was paralleled by selectively reduced task-related activation in the left ventral IFG, an area specifically implicated in semantic retrieval processes. Under atDCS, resting-state fMRI revealed increased connectivity of the left IFG and additional major hubs overlapping with the language network. In conclusion, atDCS modulates endogenous low-frequency oscillations in a distributed set of functionally connected brain areas, possibly inducing more efficient processing in critical task-relevant areas and improved behavioral performance.
Summary in another language
Subject (DDC)
150 Psychology
Keywords
Electrical brain stimulation,cognitive performance,atDCS,fMRI
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690MEINZER, Marcus, Daria ANTONENKO, Robert LINDENBERG, Stefan HETZER, Lena ULM, Keren AVIRAME, Tobias FLAISCH, Agnes FLÖEL, 2012. Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation. In: Journal of Neuroscience. 32(5), pp. 1859-1866. ISSN 0270-6474. eISSN 1529-2401. Available under: doi: 10.1523/JNEUROSCI.4812-11.2012
BibTex
@article{Meinzer2012-02-01Elect-21946,
  year={2012},
  doi={10.1523/JNEUROSCI.4812-11.2012},
  title={Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation},
  number={5},
  volume={32},
  issn={0270-6474},
  journal={Journal of Neuroscience},
  pages={1859--1866},
  author={Meinzer, Marcus and Antonenko, Daria and Lindenberg, Robert and Hetzer, Stefan and Ulm, Lena and Avirame, Keren and Flaisch, Tobias and Flöel, Agnes}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/21946">
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Flaisch, Tobias</dc:creator>
    <dc:creator>Flöel, Agnes</dc:creator>
    <dcterms:abstract xml:lang="eng">Excitatory anodal transcranial direct current stimulation (atDCS) can improve human cognitive functions, but neural underpinnings of its mode of action remain elusive. In a cross-over placebo ("sham") controlled study we used functional magnetic resonance imaging (fMRI) to investigate neurofunctional correlates of improved language functions induced by atDCS over a core language area, the left inferior frontal gyrus (IFG). Intrascanner transcranial direct current stimulation-induced changes in overt semantic word generation assessed behavioral modulation; task-related and task-independent (resting-state) fMRI characterized language network changes. Improved word-retrieval during atDCS was paralleled by selectively reduced task-related activation in the left ventral IFG, an area specifically implicated in semantic retrieval processes. Under atDCS, resting-state fMRI revealed increased connectivity of the left IFG and additional major hubs overlapping with the language network. In conclusion, atDCS modulates endogenous low-frequency oscillations in a distributed set of functionally connected brain areas, possibly inducing more efficient processing in critical task-relevant areas and improved behavioral performance.</dcterms:abstract>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/21946"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-19T10:21:33Z</dc:date>
    <dc:creator>Meinzer, Marcus</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:bibliographicCitation>The Journal of Neuroscience ; 32 (2012), 5. - S. 1859-1866</dcterms:bibliographicCitation>
    <dc:contributor>Antonenko, Daria</dc:contributor>
    <dc:contributor>Meinzer, Marcus</dc:contributor>
    <dc:contributor>Avirame, Keren</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/21946/2/Meinzer_219469.pdf"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dcterms:issued>2012-02-01</dcterms:issued>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:contributor>Flaisch, Tobias</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/21946/2/Meinzer_219469.pdf"/>
    <dc:contributor>Ulm, Lena</dc:contributor>
    <dc:creator>Avirame, Keren</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-19T10:21:33Z</dcterms:available>
    <dc:contributor>Flöel, Agnes</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Antonenko, Daria</dc:creator>
    <dc:creator>Lindenberg, Robert</dc:creator>
    <dc:creator>Hetzer, Stefan</dc:creator>
    <dc:contributor>Hetzer, Stefan</dc:contributor>
    <dcterms:title>Electrical Brain Stimulation Improves Cognitive Performance by Modulating Functional Connectivity and Task-Specific Activation</dcterms:title>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Ulm, Lena</dc:creator>
    <dc:contributor>Lindenberg, Robert</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
  </rdf:Description>
</rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Contact
URL of original publication
Test date of URL
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
Yes
Refereed