Development of large-scale functional networks over the lifespan

Cite This

Files in this item

Checksum: MD5:914a86d5fab2a4cb1ea8176d439e9777

SCHLEE, Winfried, Vera LEIRER, Stephan KOLASSA, Franka THURM, Thomas ELBERT, Iris-Tatjana KOLASSA, 2012. Development of large-scale functional networks over the lifespan. In: Neurobiology of Aging. 33(10), pp. 2411-2421. ISSN 0197-4580. eISSN 1558-1497. Available under: doi: 10.1016/j.neurobiolaging.2011.11.031

@article{Schlee2012-10Devel-21862, title={Development of large-scale functional networks over the lifespan}, year={2012}, doi={10.1016/j.neurobiolaging.2011.11.031}, number={10}, volume={33}, issn={0197-4580}, journal={Neurobiology of Aging}, pages={2411--2421}, author={Schlee, Winfried and Leirer, Vera and Kolassa, Stephan and Thurm, Franka and Elbert, Thomas and Kolassa, Iris-Tatjana} }

Elbert, Thomas 2013-02-18T08:28:10Z 2012-10 Kolassa, Iris-Tatjana eng 2013-02-18T08:28:10Z terms-of-use Schlee, Winfried Development of large-scale functional networks over the lifespan Thurm, Franka Schlee, Winfried Kolassa, Iris-Tatjana The development of large-scale functional organization of the human brain across the lifespan is not well understood. Here we used magnetoencephalographic recordings of 53 adults (ages 18–89) to characterize functional brain networks in the resting state. Slow frequencies engage larger networks than higher frequencies and show different development over the lifespan. Networks in the delta (2–4 Hz) frequency range decrease, while networks in the beta/gamma frequency range (> 16 Hz) increase in size with advancing age. Results show that the right frontal lobe and the temporal areas in both hemispheres are important relay stations in the expanding high-frequency networks. Neuropsychological tests confirmed the tendency of cognitive decline with older age. The decrease in visual memory and visuoconstructive functions was strongly associated with the age-dependent enhancement of functional connectivity in both temporal lobes. Using functional network analysis this study elucidates important neuronal principles underlying age-related cognitive decline paving mental deterioration in senescence. Neurobiology of Aging ; 33 (2012), 10. - S. 2411-2421 Kolassa, Stephan Thurm, Franka Elbert, Thomas Leirer, Vera Leirer, Vera Kolassa, Stephan

Downloads since Oct 1, 2014 (Information about access statistics)

Schlee_218623.pdf 584

This item appears in the following Collection(s)

Search KOPS


My Account