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Integrin-mediated internalization of Staphylococcus aureus does not require vinculin

Integrin-mediated internalization of Staphylococcus aureus does not require vinculin

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Prüfsumme: MD5:299914ed4a39d013a55f69b99503fe50

BORISOVA, Marina, Yong SHI, Alexander BUNTRU, Susanne WÖRNER, Wolfgang H. ZIEGLER, Christof HAUCK, 2013. Integrin-mediated internalization of Staphylococcus aureus does not require vinculin. In: BMC Cell Biology. 14(1), 2. ISSN 1471-2121. eISSN 1471-2121

@article{Borisova2013Integ-21823, title={Integrin-mediated internalization of Staphylococcus aureus does not require vinculin}, year={2013}, doi={10.1186/1471-2121-14-2}, number={1}, volume={14}, issn={1471-2121}, journal={BMC Cell Biology}, author={Borisova, Marina and Shi, Yong and Buntru, Alexander and Wörner, Susanne and Ziegler, Wolfgang H. and Hauck, Christof}, note={Article Number: 2} }

eng BMC Cell Biology ; 14 (2013). - 2 Wörner, Susanne 2013 Shi, Yong Ziegler, Wolfgang H. Buntru, Alexander Background: Disease manifestations of Staphylococcus aureus are connected to the fibronectin (Fn)-binding<br />capacity of these Gram-positive pathogens. Fn deposition on the surface of S. aureus allows engagement of α5β1 integrins and triggers uptake by host cells. For several integrin- and actin-associated cytoplasmic proteins, including FAK, Src, N-WASP, tensin and cortactin, a functional role during bacterial invasion has been demonstrated. As<br />reorganization of the actin cytoskeleton is critical for bacterial entry, we investigated whether vinculin, an essential protein linking integrins with the actin cytoskeleton, may contribute to the integrin-mediated internalization of S. aureus.<br />Results: Complementation of vinculin in vinculin -/- cells, vinculin overexpression, as well as shRNA-mediated vinculin knock-down in different eukaryotic cell types demonstrate, that vinculin does not have a functional role during the integrin-mediated uptake of S. aureus.<br />Conclusions: Our results suggest that vinculin is insignificant for the integrin-mediated uptake of S. aureus despite the critical role of vinculin as a linker between integrins and F-actin. Borisova, Marina deposit-license Buntru, Alexander 2013-02-27T11:24:34Z Borisova, Marina Ziegler, Wolfgang H. Integrin-mediated internalization of Staphylococcus aureus does not require vinculin 2013-02-27T11:24:34Z Hauck, Christof Hauck, Christof Shi, Yong Wörner, Susanne

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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