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The potential of dietary polyunsaturated fatty acids to modulate eicosanoid synthesis and reproduction in Daphnia magna : A gene expression approach

The potential of dietary polyunsaturated fatty acids to modulate eicosanoid synthesis and reproduction in Daphnia magna : A gene expression approach

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SCHLOTZ, Nina, Jesper Givskov SØRENSEN, Dominik MARTIN-CREUZBURG, 2012. The potential of dietary polyunsaturated fatty acids to modulate eicosanoid synthesis and reproduction in Daphnia magna : A gene expression approach. In: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 162(4), pp. 449-454. ISSN 1095-6433. eISSN 1531-4332. Available under: doi: 10.1016/j.cbpa.2012.05.004

@article{Schlotz2012-08poten-21532, title={The potential of dietary polyunsaturated fatty acids to modulate eicosanoid synthesis and reproduction in Daphnia magna : A gene expression approach}, year={2012}, doi={10.1016/j.cbpa.2012.05.004}, number={4}, volume={162}, issn={1095-6433}, journal={Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology}, pages={449--454}, author={Schlotz, Nina and Sørensen, Jesper Givskov and Martin-Creuzburg, Dominik} }

2013-02-07T13:23:08Z eng 2012-08 Martin-Creuzburg, Dominik Sørensen, Jesper Givskov deposit-license 2013-02-07T13:23:08Z Comparative biochemistry and physiology : A, Molecular & integrative physiology ; 162 (2012), 4. - S. 449-454 Schlotz, Nina Nutritional ecology of the aquatic model genus Daphnia has received much attention in past years in particular with regard to dietary polyunsaturated fatty acids (PUFAs) which are crucial for growth and reproduction. Besides their significant role as membrane components, C20 PUFAs serve as precursors for eicosanoids, hormone-like mediators of reproduction, immunity and ion transport physiology. In the present study we investigate transcriptomic changes in Daphnia magna in response to different algal food organisms substantially differing in their PUFA composition using quantitative real-time PCR and relate them to concomitantly documented life history data. The selection of target genes includes representatives that have previously been shown to be responsive to the eicosanoid biosynthesis inhibitor ibuprofen. The beneficial effect of C20 PUFA-rich food on reproduction and population growth rates was accompanied by an increased vitellogenin (DmagVtg1) gene expression in D. magna. Additionally, genes involved in eicosanoid signaling were particularly influenced by dietary C20 PUFA availability. For example, the cyclooxygenase gene (Cox), coding for a central enzyme in the eicosanoid pathway, was highly responsive to the food treatments. Our results suggest that dietary PUFAs are fundamental in D. magna physiology as substrate for eicosanoid synthesis and that these eicosanoids are important for D. magna reproduction. Schlotz, Nina Martin-Creuzburg, Dominik The potential of dietary polyunsaturated fatty acids to modulate eicosanoid synthesis and reproduction in Daphnia magna : A gene expression approach Sørensen, Jesper Givskov

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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