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Low-resolution structure of recombinant human granulocyte-macrophage colony stimulating factor

Low-resolution structure of recombinant human granulocyte-macrophage colony stimulating factor

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DIEDERICHS, Kay, Steven JACQUES, Tom BOONE, P. Andrew KARPLUS, 1991. Low-resolution structure of recombinant human granulocyte-macrophage colony stimulating factor. In: Journal of Molecular Biology. 221(1), pp. 55-60. ISSN 0022-2836. eISSN 1089-8638

@article{Diederichs1991Low-r-20869, title={Low-resolution structure of recombinant human granulocyte-macrophage colony stimulating factor}, year={1991}, doi={10.1016/0022-2836(91)80203-7}, number={1}, volume={221}, issn={0022-2836}, journal={Journal of Molecular Biology}, pages={55--60}, author={Diederichs, Kay and Jacques, Steven and Boone, Tom and Karplus, P. Andrew} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/20869"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-11-16T06:49:22Z</dcterms:available> <dc:contributor>Boone, Tom</dc:contributor> <dc:creator>Diederichs, Kay</dc:creator> <dcterms:title>Low-resolution structure of recombinant human granulocyte-macrophage colony stimulating factor</dcterms:title> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:issued>1991</dcterms:issued> <dc:creator>Karplus, P. Andrew</dc:creator> <dc:contributor>Diederichs, Kay</dc:contributor> <dc:creator>Boone, Tom</dc:creator> <dc:language>eng</dc:language> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/20869"/> <dc:contributor>Jacques, Steven</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-11-16T06:49:22Z</dc:date> <dcterms:abstract xml:lang="eng">A recombinant form of human granulocyte-macrophage colony stimulating factor (GM-CSF) which contains no carbohydrate has been crystallized. Multiple isomorphous replacement analysis using five heavy-atom derivatives has yielded an image of the structure at 6Åresolution that showed two molecules per asymmetric unit and allowed determination of the non-crystallographic symmetry transformation. The 6Åresolution result shows that the core of GM-CSF consists of four helices. The angles at which the helices pack together distinguishes this structure from known antiparallel four-helix bundle proteins. Consideration of the amino acid sequence properties and previous structural characterizations of GM-CSF leads to an assignment of the probable protein segments that form the helices.</dcterms:abstract> <dc:creator>Jacques, Steven</dc:creator> <dc:contributor>Karplus, P. Andrew</dc:contributor> <dcterms:bibliographicCitation>Journal of Molecular Biology ; 221 (1991), 1. - S. 55-60</dcterms:bibliographicCitation> <dc:rights>deposit-license</dc:rights> </rdf:Description> </rdf:RDF>

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