Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting

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Datum
2012
Autor:innen
Volberg, Gregor
Wimber, Maria
Raabe, Markus
Greenlee, Mark
Bäuml, Karl-Heinz
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Wie das synchronisierte Gehirn Langzeitgedächtnisinhalte formt
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Erschienen in
Journal of Neuroscience ; 32 (2012), 42. - S. 14742-14751. - ISSN 0270-6474. - eISSN 1529-2401
Zusammenfassung
Neural synchronization between distant cell assemblies is crucial for the formation of new memories. To date, however, it remains unclear whether higher-order brain regions can adaptively regulate neural synchrony to control memory processing in humans. We explored this question in two experiments using a voluntary forgetting task. In the first experiment, we simultaneously recorded electroencephalography along with fMRI. The results show that a reduction in neural synchrony goes hand-in-hand with a BOLD signal increase in the left dorsolateral prefrontal cortex (dlPFC) when participants are cued to forget previously studied information. In the
second experiment, we directly stimulated the left dlPFC with repetitive transcranial magnetic stimulation during the same task, and show that such stimulation specifically boosts the behavioral forgetting effect and induces a reduction in neural synchrony. These results suggest that prefrontally driven downregulation of long-range neural synchronization mediates goal-directed forgetting of long-term memories.
Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Fogetting,Episodic Memory,fMRI,EEG,rTMS,dlPFC,Oscillations
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Zitieren
ISO 690HANSLMAYR, Simon, Gregor VOLBERG, Maria WIMBER, Nora OEHLER, Tobias STAUDIGL, Thomas HARTMANN, Markus RAABE, Mark GREENLEE, Karl-Heinz BÄUML, 2012. Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting. In: Journal of Neuroscience. 32(42), pp. 14742-14751. ISSN 0270-6474. eISSN 1529-2401. Available under: doi: 10.1523/JNEUROSCI.1777-12.2012
BibTex
@article{Hanslmayr2012-10-17Prefr-20739,
  year={2012},
  doi={10.1523/JNEUROSCI.1777-12.2012},
  title={Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting},
  number={42},
  volume={32},
  issn={0270-6474},
  journal={Journal of Neuroscience},
  pages={14742--14751},
  author={Hanslmayr, Simon and Volberg, Gregor and Wimber, Maria and Oehler, Nora and Staudigl, Tobias and Hartmann, Thomas and Raabe, Markus and Greenlee, Mark and Bäuml, Karl-Heinz}
}
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