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Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting

Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting

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Prüfsumme: MD5:0d948348b92a788e7d42ca8355eefa6f

HANSLMAYR, Simon, Gregor VOLBERG, Maria WIMBER, Nora OEHLER, Tobias STAUDIGL, Thomas HARTMANN, Markus RAABE, Mark GREENLEE, Karl-Heinz BÄUML, 2012. Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting. In: Journal of Neuroscience. 32(42), pp. 14742-14751. ISSN 0270-6474. eISSN 1529-2401

@article{Hanslmayr2012-10-17Prefr-20739, title={Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting}, year={2012}, doi={10.1523/JNEUROSCI.1777-12.2012}, number={42}, volume={32}, issn={0270-6474}, journal={Journal of Neuroscience}, pages={14742--14751}, author={Hanslmayr, Simon and Volberg, Gregor and Wimber, Maria and Oehler, Nora and Staudigl, Tobias and Hartmann, Thomas and Raabe, Markus and Greenlee, Mark and Bäuml, Karl-Heinz} }

Raabe, Markus Greenlee, Mark Prefrontally Driven Downregulation of Neural Synchrony Mediates Goal-Directed Forgetting Volberg, Gregor deposit-license Neural synchronization between distant cell assemblies is crucial for the formation of new memories. To date, however, it remains unclear whether higher-order brain regions can adaptively regulate neural synchrony to control memory processing in humans. We explored this question in two experiments using a voluntary forgetting task. In the first experiment, we simultaneously recorded electroencephalography along with fMRI. The results show that a reduction in neural synchrony goes hand-in-hand with a BOLD signal increase in the left dorsolateral prefrontal cortex (dlPFC) when participants are cued to forget previously studied information. In the<br />second experiment, we directly stimulated the left dlPFC with repetitive transcranial magnetic stimulation during the same task, and show that such stimulation specifically boosts the behavioral forgetting effect and induces a reduction in neural synchrony. These results suggest that prefrontally driven downregulation of long-range neural synchronization mediates goal-directed forgetting of long-term memories. Staudigl, Tobias Bäuml, Karl-Heinz Hartmann, Thomas Greenlee, Mark Wimber, Maria Wimber, Maria Volberg, Gregor The Journal of Neuroscience ; 32 (2012), 42. - S. 14742-14751 Hanslmayr, Simon 2012-10-17 eng Hartmann, Thomas 2012-11-15T10:14:35Z Bäuml, Karl-Heinz Raabe, Markus Oehler, Nora Oehler, Nora Staudigl, Tobias Hanslmayr, Simon 2012-11-15T10:14:35Z

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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