Dose shift effects on an apomorphine-elicited response
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Medical Science Research. 2000, 28, pp. 39-42. ISSN 0269-8951
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Apomorphine (Apo) a dopaminergic agonist, elicited protracted bouts of pecking when injected intramuscularly into pigeons. Repeated injections of either a small or a large dose of Apo into two separate groups of pigeons led to progressive increments in pecking up to two different asymptotic response levels (dose-related sensitization). A subsequent switch of the Apo doses between the groups yielded two statistically undistinguishable asymptotic response levels. A smaller dose of Apo induced a significantly higher asymptotic response if the pigeons pre-treated with a larger dose than if they had not. The results are discussed in relation to a simple classical conditioning model of sensitization, and are related to behavioural contrast phenomena that occur in conventional conditioning paradigms involving changes of food reward magnitudes.
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150 Psychologie
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DELIUS, Juan, Adriana GODOY, Martina SIEMANN, 2000. Dose shift effects on an apomorphine-elicited response. In: Medical Science Research. 2000, 28, pp. 39-42. ISSN 0269-8951BibTex
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title={Dose shift effects on an apomorphine-elicited response},
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<dcterms:abstract xml:lang="eng">Apomorphine (Apo) a dopaminergic agonist, elicited protracted bouts of pecking when injected intramuscularly into pigeons. Repeated injections of either a small or a large dose of Apo into two separate groups of pigeons led to progressive increments in pecking up to two different asymptotic response levels (dose-related sensitization). A subsequent switch of the Apo doses between the groups yielded two statistically undistinguishable asymptotic response levels. A smaller dose of Apo induced a significantly higher asymptotic response if the pigeons pre-treated with a larger dose than if they had not. The results are discussed in relation to a simple classical conditioning model of sensitization, and are related to behavioural contrast phenomena that occur in conventional conditioning paradigms involving changes of food reward magnitudes.</dcterms:abstract>
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