Synthesis of 4′-C-alkylated-5-iodo-2′-deoxypyrimidine nucleosides

Strittmatter, Tobias; Aschenbrenner, Joos; Hardt, Normann; Marx, Andreas

Synthesis of 4′-C-alkylated-5-iodo-2′-deoxypyrimidine nucleosides

Files

strittmatter_206657.pdf(215.32 KB)

Date

2013

Publication type

Journal article

Published in

Arkivoc ; 2013, 2. - pp. 46-59. - ISSN 1551-7004. - eISSN 1551-7012

Abstract

Starting from available ribose-building blocks, the 4′-C-methyl-, 4′-C-ethyl- and the new 4′-Cpropyl-substituted deoxyuridines were synthesized. Afterwards we converted 4′-C-alkylated-2′- deoxyuridines into the corresponding 4′-C-alkylated-5-iodo-2′-deoxyuridines 3a-c and those in turn into the 4′-C-alkylated-5-iodo-2′-deoxycytidines 4a-c.

Subject (DDC)

540 Chemistry

Keywords

DNA replication,nucleoside analogues,4′-C-alkylation,antiviral agents,carbohydrate,halogenation

Cite This

ISO 690

STRITTMATTER, Tobias, Joos ASCHENBRENNER, Normann HARDT, Andreas MARX, 2013. Synthesis of 4′-C-alkylated-5-iodo-2′-deoxypyrimidine nucleosides. In: Arkivoc(2), pp. 46-59. ISSN 1551-7004. eISSN 1551-7012

BibTex

@article{Strittmatter2013Synth-20665,
  year={2013},
  title={Synthesis of 4′-C-alkylated-5-iodo-2′-deoxypyrimidine nucleosides},
  number={2},
  issn={1551-7004},
  journal={Arkivoc},
  pages={46--59},
  author={Strittmatter, Tobias and Aschenbrenner, Joos and Hardt, Normann and Marx, Andreas}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/20665">
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:contributor>Hardt, Normann</dc:contributor>
    <dc:creator>Aschenbrenner, Joos</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:creator>Marx, Andreas</dc:creator>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/20665"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-13T10:08:30Z</dc:date>
    <dc:creator>Strittmatter, Tobias</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:abstract xml:lang="eng">Starting from available ribose-building blocks, the 4′-C-methyl-, 4′-C-ethyl- and the new 4′-Cpropyl-substituted deoxyuridines were synthesized. Afterwards we converted 4′-C-alkylated-2′- deoxyuridines into the corresponding 4′-C-alkylated-5-iodo-2′-deoxyuridines 3a-c and those in turn into the 4′-C-alkylated-5-iodo-2′-deoxycytidines 4a-c.</dcterms:abstract>
    <dc:contributor>Strittmatter, Tobias</dc:contributor>
    <dc:language>eng</dc:language>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/20665/2/strittmatter_206657.pdf"/>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-03-13T10:08:30Z</dcterms:available>
    <dcterms:title>Synthesis of 4′-C-alkylated-5-iodo-2′-deoxypyrimidine nucleosides</dcterms:title>
    <dc:contributor>Aschenbrenner, Joos</dc:contributor>
    <dcterms:bibliographicCitation>Arkivoc ; (2013), 2. - S. 46-59</dcterms:bibliographicCitation>
    <dc:contributor>Marx, Andreas</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dcterms:issued>2013</dcterms:issued>
    <dc:creator>Hardt, Normann</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/20665/2/strittmatter_206657.pdf"/>
  </rdf:Description>
</rdf:RDF>

Bibliography of Konstanz

Yes