Derivatives of erythropoietin that are tissue protective but not erythropoietic

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LEIST, Marcel, Pietro GHEZZI, Giovanni GRASSO, Roberto BIANCHI, Pia VILLA, Maddalena FRATELLI, Costanza SAVINO, Marina BIANCHI, Jacob NIELSEN, Jens GERWIEN, Pekka KALLUNKI, Anna Kirstine LARSEN, Lone HELBOE, Søren CHRISTENSEN, Lars PEDERSEN, Mette NIELSEN, Lars TORUP, Thomas SAGER, Alessandra SFACTERIA, Serhat ERBAYRAKTAR, Zubeyde ERBAYRAKTAR, Necati GOKMEN, Osman YILMAZ, Carla CERAMI-HAND, Qiao-wen XIE, Thomas COLEMAN, Anthony CERAMI, Michael BRINES, 2004. Derivatives of erythropoietin that are tissue protective but not erythropoietic. In: Science. 305(5681), pp. 239-242. ISSN 0036-8075. eISSN 1095-9203

@article{Leist2004-07-09Deriv-20163, title={Derivatives of erythropoietin that are tissue protective but not erythropoietic}, year={2004}, doi={10.1126/science.1098313}, number={5681}, volume={305}, issn={0036-8075}, journal={Science}, pages={239--242}, author={Leist, Marcel and Ghezzi, Pietro and Grasso, Giovanni and Bianchi, Roberto and Villa, Pia and Fratelli, Maddalena and Savino, Costanza and Bianchi, Marina and Nielsen, Jacob and Gerwien, Jens and Kallunki, Pekka and Larsen, Anna Kirstine and Helboe, Lone and Christensen, Søren and Pedersen, Lars and Nielsen, Mette and Torup, Lars and Sager, Thomas and Sfacteria, Alessandra and Erbayraktar, Serhat and Erbayraktar, Zubeyde and Gokmen, Necati and Yilmaz, Osman and Cerami-Hand, Carla and Xie, Qiao-wen and Coleman, Thomas and Cerami, Anthony and Brines, Michael} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/20163"> <dc:contributor>Helboe, Lone</dc:contributor> <dcterms:bibliographicCitation>Publ. in: Science ; 305 (2004), 5681. - pp. 239-242</dcterms:bibliographicCitation> <dc:creator>Fratelli, Maddalena</dc:creator> <dc:creator>Torup, Lars</dc:creator> <dc:contributor>Savino, Costanza</dc:contributor> <dc:creator>Nielsen, Mette</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/20163"/> <dc:creator>Helboe, Lone</dc:creator> <dc:creator>Larsen, Anna Kirstine</dc:creator> <dc:creator>Xie, Qiao-wen</dc:creator> <dc:creator>Cerami-Hand, Carla</dc:creator> <dc:contributor>Ghezzi, Pietro</dc:contributor> <dc:contributor>Nielsen, Jacob</dc:contributor> <dc:creator>Erbayraktar, Zubeyde</dc:creator> <dc:contributor>Coleman, Thomas</dc:contributor> <dc:creator>Nielsen, Jacob</dc:creator> <dc:contributor>Erbayraktar, Serhat</dc:contributor> <dc:contributor>Gerwien, Jens</dc:contributor> <dc:contributor>Torup, Lars</dc:contributor> <dcterms:issued>2004-07-09</dcterms:issued> <dc:creator>Erbayraktar, Serhat</dc:creator> <dc:contributor>Sager, Thomas</dc:contributor> <dc:creator>Cerami, Anthony</dc:creator> <dc:creator>Bianchi, Roberto</dc:creator> <dc:creator>Savino, Costanza</dc:creator> <dc:contributor>Sfacteria, Alessandra</dc:contributor> <dcterms:abstract xml:lang="eng">Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype–selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyelitis at a potency and efficacy comparable to EPO.</dcterms:abstract> <dc:contributor>Yilmaz, Osman</dc:contributor> <dc:contributor>Pedersen, Lars</dc:contributor> <dc:contributor>Larsen, Anna Kirstine</dc:contributor> <dc:creator>Yilmaz, Osman</dc:creator> <dc:contributor>Bianchi, Marina</dc:contributor> <dc:contributor>Fratelli, Maddalena</dc:contributor> <dc:contributor>Cerami-Hand, Carla</dc:contributor> <dc:contributor>Erbayraktar, Zubeyde</dc:contributor> <dc:creator>Sfacteria, Alessandra</dc:creator> <dc:contributor>Nielsen, Mette</dc:contributor> <dc:creator>Bianchi, Marina</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:contributor>Cerami, Anthony</dc:contributor> <dc:contributor>Villa, Pia</dc:contributor> <dc:creator>Ghezzi, Pietro</dc:creator> <dc:contributor>Kallunki, Pekka</dc:contributor> <dc:creator>Pedersen, Lars</dc:creator> <dc:creator>Grasso, Giovanni</dc:creator> <dc:creator>Villa, Pia</dc:creator> <dc:creator>Sager, Thomas</dc:creator> <dc:creator>Brines, Michael</dc:creator> <dc:contributor>Bianchi, Roberto</dc:contributor> <dc:creator>Kallunki, Pekka</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:creator>Christensen, Søren</dc:creator> <dc:creator>Coleman, Thomas</dc:creator> <dc:creator>Gerwien, Jens</dc:creator> <dcterms:title>Derivatives of erythropoietin that are tissue protective but not erythropoietic</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-08-20T13:41:00Z</dcterms:available> <dc:contributor>Christensen, Søren</dc:contributor> <dc:contributor>Grasso, Giovanni</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Leist, Marcel</dc:contributor> <dc:contributor>Gokmen, Necati</dc:contributor> <dc:contributor>Xie, Qiao-wen</dc:contributor> <dc:creator>Gokmen, Necati</dc:creator> <dc:creator>Leist, Marcel</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-08-20T13:41:00Z</dc:date> <dc:contributor>Brines, Michael</dc:contributor> </rdf:Description> </rdf:RDF>

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