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Modeling of Pharmacokinetics and Pharmacodynamics with Application to Cancer and Arthritis

Modeling of Pharmacokinetics and Pharmacodynamics with Application to Cancer and Arthritis

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Prüfsumme: MD5:645487dfca5d29c9227f8544d1412b10

KOCH, Gilbert, 2012. Modeling of Pharmacokinetics and Pharmacodynamics with Application to Cancer and Arthritis [Dissertation]. Konstanz: University of Konstanz

@phdthesis{Koch2012Model-19472, title={Modeling of Pharmacokinetics and Pharmacodynamics with Application to Cancer and Arthritis}, year={2012}, author={Koch, Gilbert}, address={Konstanz}, school={Universität Konstanz} }

deposit-license Koch, Gilbert eng 2012 Modeling of Pharmacokinetics and Pharmacodynamics with Application to Cancer and Arthritis Mathematical modeling of pharmacokinetics / pharmacodynamics (PKPD) is an important and growing field in drug development. In this work we develop preclinical PKPD models based on fundamental biological and pharmacological principles.<br /><br />Equipped with a PKPD model, different dosing schedules could be simulated and therefore, a valuable contribution to first in human dose selection could be achieved. We consider different mathematical model figures and discuss the properties and biological basis. Such tools serve as modules for a final PKPD model. We apply ordinary and delay differential equations and especially focus on modeling of delays and lifespans in populations. We show a fundamental relationship between transit compartments and lifespan models. Moreover, we investigate the weighted least squares estimator and derive statistical characteristics of model parameter.<br /><br />We present a PKPD model to describe tumor growth and anticancer effects for mono- and combination therapy. Further, we construct a PKPD model for arthritis development and antibody effects.<br /><br />Summarizing, we develop (semi)-mechanistic mathematical PKPD models based on pharmacological assumptions and apply our models to measured data from preclinical phase. 2012-06-14T08:50:19Z 2012-06-14T08:50:19Z Koch, Gilbert

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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