PrPs: Proteins with a purpose ; Lessons from the zebrafish

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:734f0d42571098b5d464802b38bb81cf

MÁLAGA TRILLO, Edward, Emily SEMPOU, 2009. PrPs: Proteins with a purpose ; Lessons from the zebrafish. In: Prion. 3(3), pp. 129-133. ISSN 1933-6896

@article{Malaga Trillo2009PrPs:-19333, title={PrPs: Proteins with a purpose ; Lessons from the zebrafish}, year={2009}, doi={10.4161/pri.3.3.9651}, number={3}, volume={3}, issn={1933-6896}, journal={Prion}, pages={129--133}, author={Málaga Trillo, Edward and Sempou, Emily} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/19333"> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dc:rights>deposit-license</dc:rights> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-05-22T10:10:06Z</dcterms:available> <dc:contributor>Sempou, Emily</dc:contributor> <dc:creator>Sempou, Emily</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-05-22T10:10:06Z</dc:date> <dc:creator>Málaga Trillo, Edward</dc:creator> <dcterms:abstract xml:lang="eng">The best-known attribute of the prion protein (PrP) is its tendency to misfold into a rogue isoform. Much less understood is how this misfolded isoform causes deadly brain illnesses. Neurodegeneration in prion disease is often seen as a consequence of abnormal PrP function yet, amazingly little is known about the normal, physiological role of PrP. In particular, the absence of obvious phenotypes in PrP knockout mice has prevented scientists from answering this important question. Using knockdown approaches, we previously produced clear PrP loss-of-function phenotypes in zebrafish embryos. Analysis of these phenotypes revealed that PrP can modulate E-cadherin-based cell-cell adhesion, thereby controlling essential morphogenetic cell movements in the early gastrula. Our data also showed that PrP itself can elicit homophilic cell-cell adhesion and trigger intracellular signaling via Src-related kinases. Importantly, these molecular functions of PrP are conserved from fish to mammals. Here we discuss the use of the zebrafish in prion biology and how it may advance our understanding of the roles of PrP in health and disease.</dcterms:abstract> <dc:contributor>Málaga Trillo, Edward</dc:contributor> <dcterms:title>PrPs: Proteins with a purpose ; Lessons from the zebrafish</dcterms:title> <dcterms:bibliographicCitation>First publ. in: Prion ; 3 (2009), 3. - pp. 129-133</dcterms:bibliographicCitation> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/19333"/> <dcterms:issued>2009</dcterms:issued> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Malaga_PrPs.pdf 96

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto