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Calcium signaling in closely related protozoan groups (Alveolata): non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic apicomplexa (Plasmodium, Toxoplasma)

Calcium signaling in closely related protozoan groups (Alveolata): non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic apicomplexa (Plasmodium, Toxoplasma)

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PLATTNER, Helmut, Ivonne M. SEHRING, I. K. MOHAMED, Kildare MIRANDA, Wanderley DE SOUZA, Richard BILLINGTON, Armando GENAZZANI, Eva-Maria LADENBURGER, 2012. Calcium signaling in closely related protozoan groups (Alveolata): non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic apicomplexa (Plasmodium, Toxoplasma). In: Cell Calcium. 51(5), pp. 351-382. ISSN 0143-4160. eISSN 1532-1991

@article{Plattner2012-05Calci-19318, title={Calcium signaling in closely related protozoan groups (Alveolata): non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic apicomplexa (Plasmodium, Toxoplasma)}, year={2012}, doi={10.1016/j.ceca.2012.01.006}, number={5}, volume={51}, issn={0143-4160}, journal={Cell Calcium}, pages={351--382}, author={Plattner, Helmut and Sehring, Ivonne M. and Mohamed, I. K. and Miranda, Kildare and De Souza, Wanderley and Billington, Richard and Genazzani, Armando and Ladenburger, Eva-Maria} }

The importance of Ca2+ -signaling for many subcellular processes is well established in higher eukaryotes, whereas information about protozoa is restricted. Recent genome analyses have stimulated such work also with Alveolates, such as ciliates (Paramecium, Tetrahymena) and their pathogenic close relatives. the Apicomplexa (Plasmodium, Toxoplasma). Here we compare Ca<sup>2+</sup> signaling in the two closely related groups. Acidic Ca<sup>2+</sup> stores have been characterized in detail in Apicomplexa, but hardly in ciliates. Two-pore channels engaged in Ca<sup>2+</sup>-release from acidic stores in higher eukaryotes have not been stingently characterized in either group. Both groups are endowed with plasma membrane- and endoplasmic reticulum-type Ca<sup>2+</sup>-ATPases (PMCA, SERCA). respectively. Only recently was it possible to identifY in Paramecium a numberofhomologs ofryanodine and inositol 1,3,4-trisphosphate receptors (RyR, IP<sub>3</sub>R)and to localize them to widely different organelles participating in vesicle trafficking. For Apicomplexa, physiological experiments suggest the presence of related channels although their identity remains elusive. In Paramecium, IP<sub>3</sub>Rs are constitutively active in the contractile vacuole complex; RYR-related channels in alveolar sacs are activated during exocytosis stimulation, whereas in the parasites the homologous structure (inner membrane complex) may no longer function as a Ca<sup>2+</sup> store. Scrutinized comparison of the two closely related protozoan phyla may stimulate further work and elucidate adaptation to parasitic life. See also "Conclusions" section. Mohamed, I. K. Genazzani, Armando De Souza, Wanderley Calcium signaling in closely related protozoan groups (Alveolata): non-parasitic ciliates (Paramecium, Tetrahymena) vs. parasitic apicomplexa (Plasmodium, Toxoplasma) 2012-05 Plattner, Helmut 2012-05-16T10:47:41Z Sehring, Ivonne M. Ladenburger, Eva-Maria 2012-05-16T10:47:41Z First publ. in: Cell Calcium ; 51 (2012), 5. - S. 351-382 Sehring, Ivonne M. Ladenburger, Eva-Maria Miranda, Kildare Plattner, Helmut Billington, Richard Miranda, Kildare Billington, Richard De Souza, Wanderley Mohamed, I. K. Genazzani, Armando deposit-license eng

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