KOPS - Das Institutionelle Repositorium der Universität Konstanz

Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles

Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

AKERS, Walter J., Chulhong KIM, Mikhail BERENZIN, Kevin GUO, Ralph FUHRHOP, Gregory M. LANZA, Georg FISCHER, Ewald DALTROZZO, Andreas ZUMBUSCH, Xin CAI, Lihong V. WANG, Samuel ACHILEFU, 2011. Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles. In: ACS Nano. 5(1), pp. 173-182. ISSN 1936-0851. eISSN 1936-086X

@article{Akers2011-01-25Nonin-19306, title={Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles}, year={2011}, doi={10.1021/nn102274q}, number={1}, volume={5}, issn={1936-0851}, journal={ACS Nano}, pages={173--182}, author={Akers, Walter J. and Kim, Chulhong and Berenzin, Mikhail and Guo, Kevin and Fuhrhop, Ralph and Lanza, Gregory M. and Fischer, Georg and Daltrozzo, Ewald and Zumbusch, Andreas and Cai, Xin and Wang, Lihong V. and Achilefu, Samuel} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/19306"> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/19306"/> <dcterms:abstract xml:lang="eng">The contrast mechanisms used for photoacoustic tomography (PAT) and fluorescence imaging differ in subtle, but significant, ways. The design of contrast agents for each or both modalities requires an understanding of the spectral characteristics as well as intra- and intermolecular interactions that occur during formulation. We found that fluorescence quenching that occurs in the formulation of near-infrared (NIR) fluorescent dyes in nanoparticles results in enhanced contrast for PAT. The ability of the new PAT method to utilize strongly absorbing chromophores for signal generation allowed us to convert a highly fluorescent dye into an exceptionally high PA contrast material. Spectroscopic characterization of the developed NIR dye-loaded perfluorocarbon-based nanoparticles for combined fluorescence and PA imaging revealed distinct dye-dependent photophysical behavior. We demonstrate that the enhanced contrast allows detection of regional lymph nodes of rats in vivo with time-domain optical and photoacoustic imaging methods. The results further show that the use of fluorescence lifetime imaging, which is less dependent on fluorescence intensity, provides a strategic approach to bridge the disparate contrast reporting mechanisms of fluorescence and PA imaging methods.</dcterms:abstract> <dc:contributor>Fuhrhop, Ralph</dc:contributor> <dc:language>eng</dc:language> <dc:rights>deposit-license</dc:rights> <dc:contributor>Berenzin, Mikhail</dc:contributor> <dc:creator>Fuhrhop, Ralph</dc:creator> <dc:contributor>Achilefu, Samuel</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-05-16T07:06:57Z</dcterms:available> <dc:contributor>Guo, Kevin</dc:contributor> <dc:contributor>Wang, Lihong V.</dc:contributor> <dc:creator>Daltrozzo, Ewald</dc:creator> <dc:creator>Kim, Chulhong</dc:creator> <dcterms:issued>2011-01-25</dcterms:issued> <dc:contributor>Cai, Xin</dc:contributor> <dc:creator>Achilefu, Samuel</dc:creator> <dc:contributor>Kim, Chulhong</dc:contributor> <dc:creator>Berenzin, Mikhail</dc:creator> <dc:creator>Fischer, Georg</dc:creator> <dc:contributor>Zumbusch, Andreas</dc:contributor> <dc:contributor>Daltrozzo, Ewald</dc:contributor> <dc:creator>Wang, Lihong V.</dc:creator> <dc:contributor>Akers, Walter J.</dc:contributor> <dc:creator>Lanza, Gregory M.</dc:creator> <dc:contributor>Fischer, Georg</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-05-16T07:06:57Z</dc:date> <dcterms:title>Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles</dcterms:title> <dc:creator>Guo, Kevin</dc:creator> <dc:creator>Zumbusch, Andreas</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103605204-4002607-1"/> <dcterms:bibliographicCitation>Publ. in: ACS Nano ; 5 (2011), 1. - S. 173-182</dcterms:bibliographicCitation> <dc:creator>Cai, Xin</dc:creator> <dc:contributor>Lanza, Gregory M.</dc:contributor> <dc:creator>Akers, Walter J.</dc:creator> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto