Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus


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LÜNSE, Christina E., Magnus S. SCHMIDT, Valentin WITTMANN, Günter MAYER, 2011. Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus. In: ACS Chemical Biology. 6(7), pp. 675-678. ISSN 1554-8929. eISSN 1554-8937

@article{Lunse2011-07-15Carba-19285, title={Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus}, year={2011}, doi={10.1021/cb200016d}, number={7}, volume={6}, issn={1554-8929}, journal={ACS Chemical Biology}, pages={675--678}, author={Lünse, Christina E. and Schmidt, Magnus S. and Wittmann, Valentin and Mayer, Günter} }

<rdf:RDF xmlns:rdf="" xmlns:bibo="" xmlns:dc="" xmlns:dcterms="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:rights rdf:resource=""/> <dc:creator>Schmidt, Magnus S.</dc:creator> <dc:contributor>Schmidt, Magnus S.</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Mayer, Günter</dc:creator> <dc:contributor>Lünse, Christina E.</dc:contributor> <dcterms:available rdf:datatype="">2012-05-11T07:43:02Z</dcterms:available> <dc:contributor>Wittmann, Valentin</dc:contributor> <bibo:uri rdf:resource=""/> <dcterms:issued>2011-07-15</dcterms:issued> <dcterms:abstract xml:lang="eng">The glmS-riboswitch is unique among riboswitch families as it represents a metabolite-dependent ribozyme that undergoes self-cleavage upon recognition of glucosamin-6-phosphate. The glmS-riboswitch is located in the 5′-untranslated region of bacterial genes involved in cell wall biosynthesis. Therefore, this riboswitch represents a promising target for developing new antibiotics. We describe the metabolite-dependent glmS-riboswitch of pathologically relevant and vancomycin-resistant Staphylococcus aureus and the discovery and synthesis of a carba-sugar with potency similar to that of the native metabolite glucosamine-6-phosphate in modulating riboswitch activity. This compound represents a valuable lead structure for the development of antibiotics with a novel mode of action.</dcterms:abstract> <dcterms:title>Carba-sugars Activate the glmS-Riboswitch of Staphylococcus aureus</dcterms:title> <dc:contributor>Mayer, Günter</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:creator>Lünse, Christina E.</dc:creator> <dc:creator>Wittmann, Valentin</dc:creator> <dc:date rdf:datatype="">2012-05-11T07:43:02Z</dc:date> <dcterms:bibliographicCitation>Publ. in: ACS Chemical biology ; 6 (2011), 7. - S. 675-678</dcterms:bibliographicCitation> </rdf:Description> </rdf:RDF>

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