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Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors : SAR and structural insights

Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors : SAR and structural insights

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Prüfsumme: MD5:b7d251541589fdf938fb22668885e866

GRÄDLER, Ulrich, Thomas FUCHSS, Wolf-Rüdiger ULRICH, Rainer BOER, Andreas STRUB, Christian HESSLINGER, Céline ANÉZO, Kay DIEDERICHS, Andrea ZALIANI, 2011. Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors : SAR and structural insights. In: Bioorganic & Medicinal Chemistry Letters. 21(14), pp. 4228-4232. ISSN 0960-894X. eISSN 1464-3405. Available under: doi: 10.1016/j.bmcl.2011.05.073

@article{Gradler2011-07-15Novel-19253, title={Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors : SAR and structural insights}, year={2011}, doi={10.1016/j.bmcl.2011.05.073}, number={14}, volume={21}, issn={0960-894X}, journal={Bioorganic & Medicinal Chemistry Letters}, pages={4228--4232}, author={Grädler, Ulrich and Fuchß, Thomas and Ulrich, Wolf-Rüdiger and Boer, Rainer and Strub, Andreas and Hesslinger, Christian and Anézo, Céline and Diederichs, Kay and Zaliani, Andrea} }

Zaliani, Andrea Grädler, Ulrich Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause stroke or septic shock. Several classes of potent NOS inhibitors have been reported, most of them targeting the arginine binding site of the oxygenase domain. Here we disclose the SAR and the rational design of potent and selective iNOS inhibitors which may be useful as anti-inflammatory drugs. eng Grädler, Ulrich Anézo, Céline Diederichs, Kay Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors : SAR and structural insights Strub, Andreas Boer, Rainer Diederichs, Kay deposit-license Fuchß, Thomas First publ. in: Bioorganic & Medicinal Chemistry Letters ; 21 (2011), 14. - pp. 4228-4232 2011-07-15 Strub, Andreas 2012-05-10T05:43:23Z Hesslinger, Christian Boer, Rainer Ulrich, Wolf-Rüdiger Hesslinger, Christian Anézo, Céline Ulrich, Wolf-Rüdiger Zaliani, Andrea 2012-05-10T05:43:23Z Fuchß, Thomas

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