How reggies regulate regeneration and axon growth

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2012
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Cell and Tissue Research. 2012, 349(1), pp. 71-77. ISSN 0302-766X. eISSN 1432-0878. Available under: doi: 10.1007/s00441-012-1343-6
Zusammenfassung

The microdomain-forming proteins reggie-1 and reggie-2 (alias flotillins) were found to be upregulated in axon-regenerating fish retinal ganglion cells (RGCs). They were subsequently shown to be indispensible for axon regeneration and neurite extension in fish and mammals. Our current concept proposes that reggies-often together with the cellular Prion protein (PrP)-regulate the turnover of membrane and specific membrane proteins at the growth cone, which is the prerequisite for neurite elongation and guidance.

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570 Biowissenschaften, Biologie
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ISO 690STÜRMER, Claudia, 2012. How reggies regulate regeneration and axon growth. In: Cell and Tissue Research. 2012, 349(1), pp. 71-77. ISSN 0302-766X. eISSN 1432-0878. Available under: doi: 10.1007/s00441-012-1343-6
BibTex
@article{Sturmer2012-07reggi-19176,
  year={2012},
  doi={10.1007/s00441-012-1343-6},
  title={How reggies regulate regeneration and axon growth},
  number={1},
  volume={349},
  issn={0302-766X},
  journal={Cell and Tissue Research},
  pages={71--77},
  author={Stürmer, Claudia}
}
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