Hierarchical DL-Glutamic acid microspheres from polymer-induced liquid precursors

Jiang, Yuan; Gower, Laurie; Volkmer, Dirk; Cölfen, Helmut

Hierarchical DL-Glutamic acid microspheres from polymer-induced liquid precursors

Files

Yuan Hierarchical Microspheres--.pdf(1.9 MB)

Date

2011

Authors

Jiang, Yuan

Gower, Laurie

Volkmer, Dirk

Cölfen, Helmut

Publication type

Journal article

Published in

Crystal Growth & Design ; 11 (2011), 7. - pp. 3243-3249. - ISSN 1528-7483

Abstract

Nanostructured organic crystals have a broad application potential as pharmaceuticals, pigments, or catalysts. The development of facile and reproducible synthetic routes and the upscaling of the process, however, still remain a challenge. Here, we describe the synthesis of macroporous hierarchically structured microspheres with nanoplatelets as building blocks of a model organic molecule—DL-glutamic acid (DL-Glu)—via a polymer-induced liquid precursor (PILP) phase using oppositely charged polyethylene imine (PEI) as a polymeric additive. The impacts of experimental parameters such as [DL-Glu], temperature, solvent composition, and the pH value were systematically investigated for the DL-Glu morphosynthesis process. A mechanism is suggested to explain the precipitation of DL-Glu with PEI as an additive based on a multistep process: (1) the formation, growth, and coalescence of the PILP droplets; (2) the homogeneous nucleation of nanoplatelets within PILP droplets and (3) the reorientation of nanoplatelets into hierarchical microspheres. This model system can be further extended to the precipitation of other amino acids that have a net charge opposite to that of the polyelectrolyte additive.

Subject (DDC)

540 Chemistry

Cite This

ISO 690

JIANG, Yuan, Laurie GOWER, Dirk VOLKMER, Helmut CÖLFEN, 2011. Hierarchical DL-Glutamic acid microspheres from polymer-induced liquid precursors. In: Crystal Growth & Design. 11(7), pp. 3243-3249. ISSN 1528-7483. Available under: doi: 10.1021/cg200504n

BibTex

@article{Jiang2011Hiera-18748,
  year={2011},
  doi={10.1021/cg200504n},
  title={Hierarchical DL-Glutamic acid microspheres from polymer-induced liquid precursors},
  number={7},
  volume={11},
  issn={1528-7483},
  journal={Crystal Growth & Design},
  pages={3243--3249},
  author={Jiang, Yuan and Gower, Laurie and Volkmer, Dirk and Cölfen, Helmut}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/18748">
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Cölfen, Helmut</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-03-28T09:54:15Z</dcterms:available>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/18748/2/Yuan%20Hierarchical%20Microspheres--.pdf"/>
    <dcterms:title>Hierarchical DL-Glutamic acid microspheres from polymer-induced liquid precursors</dcterms:title>
    <dcterms:abstract xml:lang="eng">Nanostructured organic crystals have a broad application potential as pharmaceuticals, pigments, or catalysts. The development of facile and reproducible synthetic routes and the upscaling of the process, however, still remain a challenge. Here, we describe the synthesis of macroporous hierarchically structured microspheres with nanoplatelets as building blocks of a model organic molecule—DL-glutamic acid (DL-Glu)—via a polymer-induced liquid precursor (PILP) phase using oppositely charged polyethylene imine (PEI) as a polymeric additive. The impacts of experimental parameters such as [DL-Glu], temperature, solvent composition, and the pH value were systematically investigated for the DL-Glu morphosynthesis process. A mechanism is suggested to explain the precipitation of DL-Glu with PEI as an additive based on a multistep process: (1) the formation, growth, and coalescence of the PILP droplets; (2) the homogeneous nucleation of nanoplatelets within PILP droplets and (3) the reorientation of nanoplatelets into hierarchical microspheres. This model system can be further extended to the precipitation of other amino acids that have a net charge opposite to that of the polyelectrolyte additive.</dcterms:abstract>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/18748"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2012-03-28T09:54:15Z</dc:date>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:creator>Gower, Laurie</dc:creator>
    <dc:creator>Jiang, Yuan</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:language>eng</dc:language>
    <dc:creator>Volkmer, Dirk</dc:creator>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/29"/>
    <dc:rights>terms-of-use</dc:rights>
    <dc:contributor>Jiang, Yuan</dc:contributor>
    <dc:creator>Cölfen, Helmut</dc:creator>
    <dcterms:issued>2011</dcterms:issued>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:bibliographicCitation>First publ. in: Crystal growth &amp; design ; 11 (2011), 7. - S. 3243–3249</dcterms:bibliographicCitation>
    <dc:contributor>Volkmer, Dirk</dc:contributor>
    <dc:contributor>Gower, Laurie</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/18748/2/Yuan%20Hierarchical%20Microspheres--.pdf"/>
  </rdf:Description>
</rdf:RDF>

Bibliography of Konstanz

Yes